For research use only. Not for therapeutic Use.
Benzyl-PEG2-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Benzyl-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
| Catalog Number | I014158 |
| CAS Number | 1260001-87-3 |
| Synonyms | 2-(2-azidoethoxy)ethoxymethylbenzene |
| Molecular Formula | C11H15N3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C11H15N3O2/c12-14-13-6-7-15-8-9-16-10-11-4-2-1-3-5-11/h1-5H,6-10H2 |
| InChIKey | MMTGEJWEROOVON-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)COCCOCCN=[N+]=[N-] |
| Reference | [1]. Steinebach C, et al. A MedChem toolbox for cereblon-directed PROTACs. Medchemcomm. 2019 May 28;10(6):1037-1041. |
