For research use only. Not for therapeutic Use.
Benzyl-PEG2-CH2-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
| Catalog Number | I014163 |
| CAS Number | 1643957-26-9 |
| Synonyms | tert-butyl 2-[2-(2-phenylmethoxyethoxy)ethoxy]acetate |
| Molecular Formula | C17H26O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H26O5/c1-17(2,3)22-16(18)14-21-12-10-19-9-11-20-13-15-7-5-4-6-8-15/h4-8H,9-14H2,1-3H3 |
| InChIKey | IGVRCUZLYJDPKK-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)COCCOCCOCC1=CC=CC=C1 |
| Reference | [1]. Ottis P, et al. Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation. ACS Chem Biol. 2017 Oct 20;12(10):2570-2578. |
