For research use only. Not for therapeutic Use.
Benzyl-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I044521 |
| CAS Number | 91842-53-4 |
| Synonyms | 2-[2-(2-phenylmethoxyethoxy)ethoxy]acetic acid |
| Molecular Formula | C13H18O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C13H18O5/c14-13(15)11-18-9-7-16-6-8-17-10-12-4-2-1-3-5-12/h1-5H,6-11H2,(H,14,15) |
| InChIKey | JCPUGBBSZRZZNM-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)COCCOCCOCC(=O)O |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
