Benzyl-PEG3-Tos

• CAT Number: I014164
• CAS Number: 98627-22-6
• Molecular Formula: C18H22O5S
• Molecular Weight: 350.43
• Purity: ≥95%
• Synonyms: Benzyl-PEG3-Tos;2-(2-(benzyloxy)ethoxy)ethyl 4-methylbenzenesulfonate
• Target: PROTAC Linkers
• Solubility: Soluble in DMSO
• IUPAC Name: 2-(2-phenylmethoxyethoxy)ethyl 4-methylbenzenesulfonate
• InChI: InChI=1S/C18H22O5S/c1-16-7-9-18(10-8-16)24(19,20)23-14-13-21-11-12-22-15-17-5-3-2-4-6-17/h2-10H,11-15H2,1H3
• InChIKey: NFEMXFVBUWGQRW-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCC2=CC=CC=C2

Benzyl-PEG3-Tos（Cat No.:I014164）is a bioconjugate compound used in drug delivery and molecular biology applications. It consists of a benzyl group attached to a polyethylene glycol (PEG3) chain, with a tosyl group (Tos) that can be used for selective conjugation in chemical reactions. The PEG3 segment enhances the solubility, stability, and biocompatibility of the compound, making it suitable for use in therapeutic and diagnostic applications. The tosyl group is a protective group that can be cleaved under specific conditions, allowing for controlled release or conjugation to other molecules, such as drugs, peptides, or antibodies.

Reference

1: Kim HJ, Miyata K, Nomoto T, Zheng M, Kim A, Liu X, Cabral H, Christie RJ, Nishiyama N, Kataoka K. siRNA delivery from triblock copolymer micelles with spatially-ordered compartments of PEG shell, siRNA-loaded intermediate layer, and hydrophobic core. Biomaterials. 2014 May;35(15):4548-56. doi: 10.1016/j.biomaterials.2014.02.016. Epub 2014 Mar 6. PubMed PMID: 24613051.2: Acton AL, Fante C, Flatley B, Burattini S, Hamley IW, Wang Z, Greco F, Hayes W. Janus PEG-based dendrimers for use in combination therapy: controlled multi-drug loading and sequential release. Biomacromolecules. 2013 Feb 11;14(2):564-74. doi: 10.1021/bm301881h. Epub 2013 Jan 18. PubMed PMID: 23305104.3: Mueller C, Capelle MA, Seyrek E, Martel S, Carrupt PA, Arvinte T, Borchard G. Noncovalent PEGylation: different effects of dansyl-, L-tryptophan-, phenylbutylamino-, benzyl- and cholesteryl-PEGs on the aggregation of salmon calcitonin and lysozyme. J Pharm Sci. 2012 Jun;101(6):1995-2008. doi: 10.1002/jps.23110. Epub 2012 Mar 23. PubMed PMID: 22447529.