For research use only. Not for therapeutic Use.
Benzyl-PEG4-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I045418 |
| CAS Number | 1027926-86-8 |
| Synonyms | 2-[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]oxane |
| Molecular Formula | C20H32O6 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H32O6/c1-2-6-19(7-3-1)18-24-15-14-22-11-10-21-12-13-23-16-17-26-20-8-4-5-9-25-20/h1-3,6-7,20H,4-5,8-18H2 |
| InChIKey | KNXMANKMVQASTE-UHFFFAOYSA-N |
| SMILES | C1CCOC(C1)OCCOCCOCCOCCOCC2=CC=CC=C2 |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
