For research use only. Not for therapeutic Use.
Benzyl-PEG5-alcohol(Cat No.:I014167) is a benzyl polyethylene glycol (PEG) linker. PEG linkers are commonly employed in the development of antibody-drug conjugates (ADCs) and drug delivery methods. The PEG moiety imparts solubility, stability, and flexibility to the linker, while the benzyl group allows for conjugation to various molecules, such as antibodies or drugs. This linker enables the attachment of payloads or therapeutic agents to antibodies, facilitating targeted delivery to specific cells or tissues. Benzyl-PEG5-alcohol and similar PEG linkers play a crucial role in enhancing the efficacy and selectivity of ADCs and other drug delivery systems.
Catalog Number | I014167 |
CAS Number | 86259-87-2 |
Synonyms | Benzyl-PEG5-alcohol;1-phenyl-2,5,8,11-tetraoxatridecan-13-ol |
Molecular Formula | C15H24O5 |
Purity | ≥95% |
Target | PROTAC Linkers |
Solubility | Soluble in DMSO |
Storage | 2-8°C |
IUPAC Name | 2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethanol |
InChI | InChI=1S/C15H24O5/c16-6-7-17-8-9-18-10-11-19-12-13-20-14-15-4-2-1-3-5-15/h1-5,16H,6-14H2 |
InChIKey | QDPIVUQXPXUNLN-UHFFFAOYSA-N |
SMILES | C1=CC=C(C=C1)COCCOCCOCCOCCO |
Reference | </br>1: Kim HJ, Miyata K, Nomoto T, Zheng M, Kim A, Liu X, Cabral H, Christie RJ, Nishiyama N, Kataoka K. siRNA delivery from triblock copolymer micelles with spatially-ordered compartments of PEG shell, siRNA-loaded intermediate layer, and hydrophobic core. Biomaterials. 2014 May;35(15):4548-56. doi: 10.1016/j.biomaterials.2014.02.016. Epub 2014 Mar 6. PubMed PMID: 24613051.</br>2: Acton AL, Fante C, Flatley B, Burattini S, Hamley IW, Wang Z, Greco F, Hayes W. Janus PEG-based dendrimers for use in combination therapy: controlled multi-drug loading and sequential release. Biomacromolecules. 2013 Feb 11;14(2):564-74. doi: 10.1021/bm301881h. Epub 2013 Jan 18. PubMed PMID: 23305104.</br>3: Mueller C, Capelle MA, Seyrek E, Martel S, Carrupt PA, Arvinte T, Borchard G. Noncovalent PEGylation: different effects of dansyl-, L-tryptophan-, phenylbutylamino-, benzyl- and cholesteryl-PEGs on the aggregation of salmon calcitonin and lysozyme. J Pharm Sci. 2012 Jun;101(6):1995-2008. doi: 10.1002/jps.23110. Epub 2012 Mar 23. PubMed PMID: 22447529. </br> </br> |