For research use only. Not for therapeutic Use.
Benzyl-PEG6-alcohol（Cat No.:I014171）is a compound consisting of a benzyl group attached to a polyethylene glycol (PEG) chain of six ethylene glycol units, with a hydroxyl (-OH) group at the terminal end. This structure provides both hydrophilic and hydrophobic characteristics, making it useful in various biomedical applications. The PEG6 chain increases solubility and stability in aqueous environments, while the benzyl group can facilitate molecular interactions, such as in drug delivery systems, protein conjugation, or bioorthogonal chemistry. It is commonly used in developing targeted therapies, molecular imaging, and creating conjugates for improved pharmacokinetics.
| Catalog Number | I014171 |
| CAS Number | 57671-28-0 |
| Synonyms | Benzyl-PEG6-alcohol;1-phenyl-2,5,8,11,14-pentaoxahexadecan-16-ol |
| Molecular Formula | C17H28O6 |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| Solubility | Soluble in DMSO |
| IUPAC Name | 2-[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol |
| InChI | InChI=1S/C17H28O6/c18-6-7-19-8-9-20-10-11-21-12-13-22-14-15-23-16-17-4-2-1-3-5-17/h1-5,18H,6-16H2 |
| InChIKey | UMUSOTNGYAALST-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)COCCOCCOCCOCCOCCO |
| Reference | </br>1: Kim HJ, Miyata K, Nomoto T, Zheng M, Kim A, Liu X, Cabral H, Christie RJ, Nishiyama N, Kataoka K. siRNA delivery from triblock copolymer micelles with spatially-ordered compartments of PEG shell, siRNA-loaded intermediate layer, and hydrophobic core. Biomaterials. 2014 May;35(15):4548-56. doi: 10.1016/j.biomaterials.2014.02.016. Epub 2014 Mar 6. PubMed PMID: 24613051.</br>2: Acton AL, Fante C, Flatley B, Burattini S, Hamley IW, Wang Z, Greco F, Hayes W. Janus PEG-based dendrimers for use in combination therapy: controlled multi-drug loading and sequential release. Biomacromolecules. 2013 Feb 11;14(2):564-74. doi: 10.1021/bm301881h. Epub 2013 Jan 18. PubMed PMID: 23305104.</br>3: Mueller C, Capelle MA, Seyrek E, Martel S, Carrupt PA, Arvinte T, Borchard G. Noncovalent PEGylation: different effects of dansyl-, L-tryptophan-, phenylbutylamino-, benzyl- and cholesteryl-PEGs on the aggregation of salmon calcitonin and lysozyme. J Pharm Sci. 2012 Jun;101(6):1995-2008. doi: 10.1002/jps.23110. Epub 2012 Mar 23. PubMed PMID: 22447529. </br> </br> |
