Benzyl-PEG7-alcohol

• CAT Number: I014174
• CAS Number: 24342-68-5
• Molecular Formula: C19H32O7
• Molecular Weight: 372.46
• Purity: ≥95%
• Synonyms: Benzyl-PEG7-alcohol;1-phenyl-2,5,8,11,14,17-hexaoxanonadecan-19-ol
• Target: PROTAC
• Solubility: Soluble in DMSO
• IUPAC Name: 2-[2-[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol
• InChI: InChI=1S/C19H32O7/c20-6-7-21-8-9-22-10-11-23-12-13-24-14-15-25-16-17-26-18-19-4-2-1-3-5-19/h1-5,20H,6-18H2
• InChIKey: VVBQKDDPSXBMMZ-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)COCCOCCOCCOCCOCCOCCO

BnO-PEG6-OH is a non-cleavable ADC linker that incorporates six units of polyethylene glycol (PEG). It is utilized in the synthesis of antibody-drug conjugates (ADCs), where it serves as a stable linkage between the antibody and the drug payload. Additionally, BnO-PEG6-OH is classified as a PEG-based PROTAC linker, enabling the construction of proteolysis-targeting chimeras (PROTACs). The PEG component provides solubility, flexibility, and biocompatibility, contributing to the overall stability and effectiveness of the ADCs or PROTACs in targeted therapeutics and drug discovery.

Reference

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