Benzyldecyldimethylammonium Chloride

• CAT Number: R044617
• CAS Number: 965-32-2
• Molecular Formula: C19H34ClN
• Molecular Weight: 311.938
• Purity: ≥95%
• Synonyms: N-Decyl-N,N-dimethyl-benzenemethanaminium Chloride; ?Benzyldecyldimethyl-ammonium Chloride; N-Decyl-N,N-dimethyl-benzenemethanaminium Chloride; Capryldimethylbenzylammonium Chloride; Decylbenzyldimethylammonium Chloride; Decyldimethylbenzylammonium C
• Storage: Store at RT
• IUPAC Name: benzyl-decyl-dimethylazanium;chloride
• InChI: InChI=1S/C19H34N.ClH/c1-4-5-6-7-8-9-10-14-17-20(2,3)18-19-15-12-11-13-16-19;/h11-13,15-16H,4-10,14,17-18H2,1-3H3;1H/q+1;/p-1
• InChIKey: TTZLKXKJIMOHHG-UHFFFAOYSA-M
• SMILES: CCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1.[Cl-]

Benzyldecyldimethylammonium Chloride (CAS 965-32-2) is a quaternary ammonium compound (QAC) with bactericidal action that is used as an active molecule in detergent formulations.It may be used as an analytical reference standard for the determination of the analyte  by chromatography based techniques.

Reference

1. J Glob Antimicrob Resist. 2018 Dec;15:188-195. doi: 10.1016/j.jgar.2018.07.004. Epub 2018 Jul 17.Pseudomonas fluorescens tolerance to benzyldimethyldodecyl ammonium chloride: Altered phenotype and cross-resistance.Sousa-Silva M(1), Simões M(1), Melo L(1), Machado I(2).

 

OBJECTIVES: Benzyldimethyldodecyl ammonium chloride (BDMDAC) is a quaternary ammonium compound (QAC) with bactericidal action that is used as an active molecule in detergent formulations. Pseudomonas fluorescens is a Gram-negative bacterium with versatile metabolism that is frequently present in biofilms on industrial surfaces. This work reports P.fluorescens adaptation to BDMDAC and subsequent concurrent reduced susceptibility to the QAC benzalkonium chloride (BAC) and the antimicrobial ciprofloxacin (CIP).


METHODS: Stepwise adaptation to increasing concentrations of BDMDAC was easily achieved and caused changes in the bacterial phenotype of P. fluorescens. Adaptation was evaluated through minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) determination and was subsequently confirmed by time-kill curves. Biofilm phenotype (biomass and number of cells) was characterised for the adapted and reference strains after treatment with BDMDAC, BAC and CIP.


RESULTS: Susceptibility to BAC and CIP was reduced in adapted P. fluorescens. Biofilms developed by the adapted strain had 20% more mass and a higher number of bacteria (2 log).


CONCLUSIONS: This study revealed that exposure to sublethal concentrations of BDMDAC may select tolerant strains to that product as well as to related products and unrelated antimicrobial agents.


2.Danaher, Martin, and Kieran Jordan. "Identification of existing and emerging chemical residue contamination concerns in milk." Irish Journal of Agricultural and Food Research (2013): 173-183.

3.Van Bruijnsvoort, Michel, et al. "Determination of residues of quaternary ammonium disinfectants in food products by liquid chromatography-tandem mass spectrometry." Journal of AOAC International 87.4 (2004): 1016-1020.