Bepotastine Besilate

• CAT Number: A000247
• CAS Number: 190786-44-8
• Molecular Formula: C27H31ClN2O6S
• Molecular Weight: 547.06
• Purity: ≥95%
• Synonyms: TAU 284
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO > 10 mM
• Storage: 0 - 4 °C for short term or -20 °C for long term
• IUPAC Name: benzenesulfonic acid;4-[4-[(S)-(4-chlorophenyl)-pyridin-2-ylmethoxy]piperidin-1-yl]butanoic acid
• InChI: InChI=1S/C21H25ClN2O3.C6H6O3S/c22-17-8-6-16(7-9-17)21(19-4-1-2-12-23-19)27-18-10-14-24(15-11-18)13-3-5-20(25)26;7-10(8,9)6-4-2-1-3-5-6/h1-2,4,6-9,12,18,21H,3,5,10-11,13-15H2,(H,25,26);1-5H,(H,7,8,9)/t21-;/m0./s1
• InChIKey: UDGHXQPQKQPSBB-BOXHHOBZSA-N
• SMILES: C1CN(CCC1O[C@@H](C2=CC=C(C=C2)Cl)C3=CC=CC=N3)CCCC(=O)O.C1=CC=C(C=C1)S(=O)(=O)O

Bepotastine Besilate（Cat No.:A000247）is a second-generation antihistamine used to treat allergic symptoms such as itching, runny nose, and watery eyes. It works by selectively blocking histamine H1 receptors, preventing the release of histamine that causes allergic reactions. Bepotastine is often formulated as an ophthalmic solution for treating allergic conjunctivitis, providing rapid relief from eye irritation and inflammation. With minimal sedative effects due to its limited crossing of the blood-brain barrier, Bepotastine is well-tolerated, making it a preferred option for managing both seasonal and perennial allergic conditions.

Overview of Clinical Research

Bepotastine Besilate is a histamine H1 receptor antagonist. It has been granted for the new molecular entity. 

Dong-A ST completed a phase I trial in Healthy volunteers in South Korea (NCT03932435) in 2020.

Reference

1: Okubo K, Ichimura M, Koyama T, Susuta Y, Izaki H. Double-blind placebo-controlled study of bepotastine besilate in pediatric patients with perennial allergic rhinitis. Expert Opin Pharmacother. 2015;16(16):2395-408. doi: 10.1517/14656566.2015.108