For research use only, not for therapeutic use.
Bepotastine Besilate（Cat No.:A000247）is a second-generation antihistamine used to treat allergic symptoms such as itching, runny nose, and watery eyes. It works by selectively blocking histamine H1 receptors, preventing the release of histamine that causes allergic reactions. Bepotastine is often formulated as an ophthalmic solution for treating allergic conjunctivitis, providing rapid relief from eye irritation and inflammation. With minimal sedative effects due to its limited crossing of the blood-brain barrier, Bepotastine is well-tolerated, making it a preferred option for managing both seasonal and perennial allergic conditions.
| Catalog Number | A000247 |
| CAS Number | 190786-44-8 |
| Synonyms | TAU 284 |
| Molecular Formula | C27H31ClN2O6S |
| Purity | ≥95% |
| Target | Histamine Receptor |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | 0 - 4 °C for short term or -20 °C for long term |
| Overview of Clinical Research | <span style=”color:#000000;”><span style=”font-family:arial,helvetica,sans-serif;”><span style=”font-size:12px;”>Bepotastine Besilate is a <span style=”orphans: 2; widows: 2;”>histamine H1 receptor antagonist. It has been granted for the new molecular entity. </span></span></span></span><br /> |
| IUPAC Name | benzenesulfonic acid;4-[4-[(S)-(4-chlorophenyl)-pyridin-2-ylmethoxy]piperidin-1-yl]butanoic acid |
| InChI | InChI=1S/C21H25ClN2O3.C6H6O3S/c22-17-8-6-16(7-9-17)21(19-4-1-2-12-23-19)27-18-10-14-24(15-11-18)13-3-5-20(25)26;7-10(8,9)6-4-2-1-3-5-6/h1-2,4,6-9,12,18,21H,3,5,10-11,13-15H2,(H,25,26);1-5H,(H,7,8,9)/t21-;/m0./s1 |
| InChIKey | UDGHXQPQKQPSBB-BOXHHOBZSA-N |
| SMILES | C1CN(CCC1O[C@@H](C2=CC=C(C=C2)Cl)C3=CC=CC=N3)CCCC(=O)O.C1=CC=C(C=C1)S(=O)(=O)O |
| Reference | 1: Okubo K, Ichimura M, Koyama T, Susuta Y, Izaki H. Double-blind placebo-controlled study of bepotastine besilate in pediatric patients with perennial allergic rhinitis. Expert Opin Pharmacother. 2015;16(16):2395-408. doi: 10.1517/14656566.2015.108 |
