For research use only. Not for therapeutic Use.
Bepridil Hydrochloride (Cat.No:I003436) is the hydrochloride salt form of bepridil, a calcium antagonist and class IV anti-arrhythmic agent. Bepridil hydrochloride blocks calcium entry through membranous calcium channels of coronary and peripheral vascular smooth muscle, thereby dilating coronary arteries and peripheral arterioles. This drug is used to treat chronic stable and variant angina pectoris. Bepridil hydrochloride has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.
| Catalog Number | I003436 |
| CAS Number | 74764-40-2 |
| Synonyms | Angopril, Bepadin, Bepridil HCl, Bepridil hydrochloride, Bepridil hydrochloride monohydrate, CERM 1978, Cordium, UNII-4W2P15D93M, Vascor;1-Pyrrolideneethanamine, beta-((2-methylpropoxy)methyl)-N-phenyl-N-(phenylmethyl)-, monohydrochloride, monohydrat |
| Molecular Formula | C24H37ClN2O2 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term or -20 °C for long term |
| IUPAC Name | N-benzyl-N-[3-(2-methylpropoxy)-2-pyrrolidin-1-ylpropyl]aniline;hydrate;hydrochloride |
| InChI | InChI=1S/C24H34N2O.ClH.H2O/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22;;/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3;1H;1H2 |
| InChIKey | UEECHQPWQHYEDE-UHFFFAOYSA-N |
| SMILES | CC(C)COCC(CN(CC1=CC=CC=C1)C2=CC=CC=C2)N3CCCC3.O.Cl |
| Reference | </br>1:Bepridil hydrochloride compared with placebo in patients with stable angina pectoris. Narahara KA, Singh BN, Karliner JS, Corday SR, Hossack KF.Am J Cardiol. 1992 Apr 9;69(11):37D-42D. PMID: 1553890 </br>2:Stability-indicating high-performance liquid chromatography assay for bepridil hydrochloride drug substance and drug products. Renzi NL, Fronheiser ME, Duong HT, Fulton DJ, Rabinowitz M.J Chromatogr. 1989 Jan 13;462:398-405. No abstract available. PMID: 2786887 </br>3:Effects of bepridil hydrochloride on cardiocirculatory dynamics, coronary vascular resistance, and cardiac output distribution in normal, conscious rats. Flaim SF, Stranieri MT, Mathiasen JR.J Cardiovasc Pharmacol. 1988 Mar;11(3):363-72. PMID: 2452931 </br>4:Bepridil hydrochloride for treatment of benign or potentially lethal ventricular arrhythmias. Nestico PF, Morganroth J, Horowitz LN, Mulhern C.Am J Cardiol. 1986 Nov 1;58(10):1001-4. PMID: 2430441 </br>5:Effects of bepridil hydrochloride on calcium-induced responses in guinea pig Langendorff heart. Gleason MM, Gill A, Brannan MD, Flaim SF.Pharmacology. 1986;33(2):76-85. PMID: 3488555 </br>6:Bepridil hydrochloride alters potential-dependent and receptor-operated calcium channels in vascular smooth muscle of rabbit aorta. Flaim SF, Ratz PH, Swigart SC, Gleason MM.J Pharmacol Exp Ther. 1985 Jul;234(1):63-71. PMID: 2409274 </br>7:Electrophysiologic, hemodynamic and metabolic effects of intravenous bepridil hydrochloride. Upward JW, Daly K, Campbell S, Bergman G, Jewitt DE.Am J Cardiol. 1985 Jun 1;55(13 Pt 1):1589-95. PMID: 3873868 |
