Berberine chloride

• CAT Number: I004389
• CAS Number: 633-65-8
• Molecular Formula: C20H18ClNO4
• Molecular Weight: 371.80
• Purity: ≥95%
• Synonyms: BBR;Umbellatine
• Target: Anticancer agent
• Solubility: 10 mM in DMSO
• Storage: <label class=
• IUPAC Name: 16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene;chloride
• InChI: InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1
• InChIKey: VKJGBAJNNALVAV-UHFFFAOYSA-M
• SMILES: COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]

Berberine chloride（Cat No.:I004389）is a natural alkaloid extracted from plants like Berberis species, known for its wide range of pharmacological effects. It exhibits antimicrobial, anti-inflammatory, and antioxidant properties, making it useful in treating infections, metabolic disorders, and inflammation-related conditions. Berberine chloride is widely studied for its potential in managing type 2 diabetes by improving insulin sensitivity and regulating blood sugar levels. It also shows promise in cardiovascular health by modulating lipid metabolism and reducing cholesterol. This compound is valuable in research exploring natural therapies for chronic diseases and metabolic disorders.

Reference

[1]. Jabbarzadeh Kaboli P, et al. Targets and mechanisms of berberine, a natural drug with potential to treat cancer with special focus on breast cancer. Eur J Pharmacol. 2014 Jun 26. pii: S0014-2999(14)00467-1.
[2]. Wang Y, et al. Berberine decreases cholesterol levels in rats through multiple mechanisms, including inhibition of cholesterol absorption. Metabolism. 2014 Jun 4. pii: S0026-0495(14)00162-0.
[3]. Yu R, et al. Berberine-induced apoptotic and autophagic death of HepG2 cells requires AMPK activation. Cancer Cell Int. 2014 Jun 11;14:49.
[4]. Albring KF, et al. Berberine acts as a natural inhibitor of Wnt/β-catenin signaling–identification of more active 13-arylalkyl derivatives. Biofactors. 2013 Nov-Dec;39(6):652-62.