Bergenin

• CAT Number: I003670
• CAS Number: 477-90-7
• Molecular Formula: C14H16O9
• Molecular Weight: 328.27
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: 3 years -20℃ powder
• IC50: < 2.5 μM (antiplasmodial) [3]
• IUPAC Name: (2R,3S,4S,4aR,10bS)-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydro-2H-pyrano[3,2-c]isochromen-6-one
• InChI: YWJXCIXBAKGUKZ-HJJNZUOJSA-N
• InChIKey: InChI=1S/C14H16O9/c1-21-11-5(16)2-4-7(9(11)18)12-13(23-14(4)20)10(19)8(17)6(3-15)22-12/h2,6,8,10,12-13,15-19H,3H2,1H3/t6-,8-,10+,12+,13-/m1/s1
• SMILES: COC1=C(C=C2C(=C1O)[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)OC2=O)O

Bergenin (Cat.No:I003670) is a natural compound found in various plants, including Bergenia species and rhubarb. It has been traditionally used in Ayurvedic and traditional Chinese medicine for its anti-inflammatory, anti-diarrheal, and anti-bacterial properties. Bergenin has been studied for its potential as a therapeutic agent in various conditions, including diabetes, inflammation, and cancer. 

Reference

1:The Phytochemical Bergenin Enhances T Helper 1 Responses and Anti-Mycobacterial Immunity by Activating the MAP Kinase Pathway in Macrophages. Dwivedi VP, Bhattacharya D, Yadav V, Singh DK, Kumar S, Singh M, Ojha D, Ranganathan A, Van Kaer L, Chattopadhyay D, Das G.Front Cell Infect Microbiol. 2017 May 1;7:149. doi: 10.3389/fcimb.2017.00149. eCollection 2017. PMID: 28507951 Free PMC Article2:Synthesis and in vitro and in vivo antitumour activity study of 11-hydroxyl esterified bergenin/cinnamic acid hybrids. Liang C, Pei S, Ju W, Jia M, Tian D, Tang Y, Mao G.Eur J Med Chem. 2017 Jun 16;133:319-328. doi: 10.1016/j.ejmech.2017.03.053. Epub 2017 Apr 3. PMID: 28395218 3:Bergenin from Peltophorum dubium: Isolation, Characterization, and Antioxidant Activities in Non-Biological Systems and Erythrocytes. de Oliveira GA, da Silva Oliveira GL, Nicolau LA, Mafud AC, Batista LF, Mascarenhas YP, de Sousa LK, David JM, Pinto LS, Alves CQ, Medeiros JV.Med Chem. 2017 Mar 6. doi: 10.2174/1573406413666170306120152. [Epub ahead of print] PMID: 28266277 4:Comparative pharmacokinetics of bergenin, a main active constituent of Saxifraga stolonifera Curt., in normal and hepatic injury rats after oral administration. Pan RH, He HM, Dai Y, Xia YF.Chin J Nat Med. 2016 Oct;14(10):776-782. doi: 10.1016/S1875-5364(16)30092-9. Epub 2016 Oct 31. PMID: 28236407 5:The natural product bergenin ameliorates lipopolysaccharide-induced acute lung injury by inhibiting NF-kappaB activition. Yang S, Yu Z, Wang L, Yuan T, Wang X, Zhang X, Wang J, Lv Y, Du G.J Ethnopharmacol. 2017 Mar 22;200:147-155. doi: 10.1016/j.jep.2017.02.013. Epub 2017 Feb 10. PMID: 28192201 6:Antianxiety activity guided isolation and characterization of bergenin from Caesalpinia digyna Rottler roots. Singh J, Kumar A, Sharma A.J Ethnopharmacol. 2017 Jan 4;195:182-187. doi: 10.1016/j.jep.2016.11.016. Epub 2016 Nov 12. PMID: 27845264 7:Bergenin attenuates renal injury by reversing mitochondrial dysfunction in ethylene glycol induced hyperoxaluric rat model. Aggarwal D, Gautam D, Sharma M, Singla SK.Eur J Pharmacol. 2016 Nov 15;791:611-621. doi: 10.1016/j.ejphar.2016.10.002. Epub 2016 Oct 5. PMID: 27717728 8:Anti-arthritic activity of 11-O-(4/’-O-methyl galloyl)-bergenin and Crassula capitella extract in rats. El-Hawary SS, Mohammed R, Abouzid S, Ali ZY, Elwekeel A.J Pharm Pharmacol. 2016 Jun;68(6):834-44. doi: 10.1111/jphp.12566. PMID: 27230134 9:Comparative effects of dexamethasone and bergenin on chronic bronchitis and their anti-inflammatory mechanisms based on NMR metabolomics. Ren X, Ma S, Wang J, Tian S, Fu X, Liu X, Li Z, Zhao B, Wang X.Mol Biosyst. 2016 May 24;12(6):1938-47. doi: 10.1039/c6mb00041j. PMID: 27098339 10:Antioxidant and Antiplasmodial Activities of Bergenin and 11-O-Galloylbergenin Isolated from Mallotus philippensis. Khan H, Amin H, Ullah A, Saba S, Rafique J, Khan K, Ahmad N, Badshah SL.Oxid Med Cell Longev. 2016;2016:1051925. doi: 10.1155/2016/1051925. Epub 2016 Feb 22. PMID: 26998192 Free PMC Article