Bersanlimab

• CAT Number: I042157
• CAS Number: 1987854-08-9
• Purity: ≥95%

Bersanlimab (BI-505) is a fully human monoclonal antibody that targets intercellular adhesion molecule-1 (ICAM-1 or CD54). Bersanlimab has anticancer effects[1].
BI-505 (1 ng/mL-1000 μg/mL) dose-dependently induces programmed cell death (PCD) in ICAM-1-expressing Ramos, Raji, and Daudi lymphoma cells[1].
Bersanlimab (BI-505; 20 mg/kg; i.p.; twice-weekly; for 21 days) significantly reduceds tumor growth and prolonges animal survival[1].

Reference

[1]. Niina Veitonmäki, et al. A human ICAM-1 antibody isolated by a function-first approach has potent macrophage-dependent antimyeloma activity in vivo. Cancer Cell. 2013 Apr 15;23(4):502-15.
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