For research use only. Not for therapeutic Use.
Besifovir（Cat No.:I004161）is an investigational nucleotide analog antiviral agent developed for the treatment of chronic hepatitis B virus (HBV) infection. It inhibits HBV DNA polymerase, effectively suppressing viral replication. Besifovir offers a promising alternative to current therapies, with studies suggesting potent antiviral efficacy, a favorable safety profile, and reduced risk of renal toxicity and bone mineral density loss compared to other nucleotide analogs. Its oral bioavailability and potential for long-term management make it a valuable candidate in the fight against HBV, aiming to improve patient outcomes and reduce disease progression.
| Catalog Number | I004161 |
| CAS Number | 441785-25-7 |
| Synonyms | LB80380; LB-80380; LB 80380; PMCDG; Besifovir;((1-((2-amino-9H-purin-9-yl)methyl)cyclopropoxy)methyl)phosphonic acid |
| Molecular Formula | C10H14N5O4P |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term or -20 °C for long term |
| IUPAC Name | [1-[(2-aminopurin-9-yl)methyl]cyclopropyl]oxymethylphosphonic acid |
| InChI | InChI=1S/C10H14N5O4P/c11-9-12-3-7-8(14-9)15(5-13-7)4-10(1-2-10)19-6-20(16,17)18/h3,5H,1-2,4,6H2,(H2,11,12,14)(H2,16,17,18) |
| InChIKey | KDNSSKPZBDNJDF-UHFFFAOYSA-N |
| SMILES | C1CC1(CN2C=NC3=CN=C(N=C32)N)OCP(=O)(O)O |
| Reference | </br>1:Two-year treatment outcome of chronic hepatitis B infection treated with besifovir vs. entecavir: results from a multicentre study. Yuen MF, Ahn SH, Lee KS, Um SH, Cho M, Yoon SK, Lee JW, Park NH, Kweon YO, Sohn JH, Lee J, Kim JA, Lai CL, Han KH.J Hepatol. 2015 Mar;62(3):526-32. doi: 10.1016/j.jhep.2014.10.026. Epub 2014 Oct 25. PMID: 25450709 </br>2:Oral antiviral therapy for hepatitis B: the case of besifovir, a new kid on the block with a long way to go. Lampertico P.Gut. 2014 Jun;63(6):869-70. doi: 10.1136/gutjnl-2013-305859. Epub 2013 Oct 25. No abstract available. PMID: 24162592 </br>3:Phase IIb multicentred randomised trial of besifovir (LB80380) versus entecavir in Asian patients with chronic hepatitis B. Lai CL, Ahn SH, Lee KS, Um SH, Cho M, Yoon SK, Lee JW, Park NH, Kweon YO, Sohn JH, Lee J, Kim JA, Han KH, Yuen MF.Gut. 2014 Jun;63(6):996-1004. doi: 10.1136/gutjnl-2013-305138. Epub 2013 Aug 26. PMID: 23979965 |
