Bestim

• CAT Number: I023292
• CAS Number: 66471-20-3
• Molecular Formula: C16H19N3O5
• Molecular Weight: 333.34
• Purity: 98%
• Synonyms: Bestim
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: N5-((S)-1-carboxy-2-(1H-indol-3-yl)ethyl)-L-glutamine
• InChI: InChI=1S/C16H19N3O5/c17-11(15(21)22)5-6-14(20)19-13(16(23)24)7-9-8-18-12-4-2-1-3-10(9)12/h1-4,8,11,13,18H,5-7,17H2,(H,19,20)(H,21,22)(H,23,24)/t11-,13-/m0/s1
• InChIKey: CATMPQFFVNKDEY-AAEUAGOBSA-N
• SMILES: O=C(O)[C@H](CC1=CNC2=C1C=CC=C2)NC(CC[C@@H](C(O)=O)N)=O

Bestim is a synthetic immunomodulatory dipeptide.

Reference

1: Kolobov AA, Kolodkin NI, Zolotarev IuA, Tathill C, Navolotskaia EV. [Interaction of the synthetic immunomodulatory dipeptide bestim with murine macrophages and thymocytes]. Bioorg Khim. 2008 Jan-Feb;34(1):43-9. Russian. PubMed PMID: 18365736.
2: Zabolotnykh NV, Vinogradova TI, Vasil’eva SN. [Activating effect of bestim on the macrophages in experimental tuberculosis of varying severity]. Probl Tuberk Bolezn Legk. 2003;(10):53-6. Russian. PubMed PMID: 14669634.
3: Tkacheva AG, Kalev OF, Dolgushina AI, Antipina TV. [Impact of Bestim on the immunological status and clinical course of ulcer]. Eksp Klin Gastroenterol. 2004;(6):29-33, 163. Russian. PubMed PMID: 16259438.
4: Rudenko MY. [IMMUNE SYSTEM DATA IN PATIENTS WITH PERSISTENT RECURENT HERPES VIRUS INFECTIONS IN DYNAMICS OF COMPLEX THERAPY]. Lik Sprava. 2015 Jul-Sep;(5-6):14-20. Russian. PubMed PMID: 27089710.
5: Vinogradova TI, Vitovskaia ML, Zabolotnykh NV, Kovalenko AL, Ariél’ BM, Shchegoleva RA. [The influence of immunotropic drugs on reparative processes in the lungs experimental chemotherapy drug resistant tuberculosis]. Eksp Klin Farmakol. 2014;77(7):11-5. Russian. PubMed PMID: 25322647.
6: Yakimets AV, Zozulya SA, Oleichik IV, Klyushnik TP. [Dynamics of clinical and biological indices of the asthenic symptom-complex during immunotropic therapy of patients with schizophrenia]. Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(3):70-76. doi: 10.17116/jnevro20181183170-76. Russian. PubMed PMID: 29652309.