BET-BAY 002

• CAT Number: I002016
• CAS Number: 1588521-78-1
• Molecular Formula: C22H18ClN5O
• Molecular Weight: 403.86
• Purity: ≥95%
• Synonyms: 2-[[(4R)-6-(4-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1]benzazepin-4-yl]methyl]-5-methyl-1,3,4-oxadiazole
• InChI: InChI=1S/C22H18ClN5O/c1-13-24-27-22-16(12-21-26-25-14(2)29-21)11-19(15-7-9-17(23)10-8-15)18-5-3-4-6-20(18)28(13)22/h3-11,16H,12H2,1-2H3/t16-/m0/s1
• InChIKey: AGYIAWHWIUZNSD-INIZCTEOSA-N
• SMILES: CC1=NN=C2N1C3=CC=CC=C3C(=CC2CC4=NN=C(O4)C)C5=CC=C(C=C5)Cl

BET-BAY 002 is a potent BET inhibitor; shows efficacy in a multiple myeloma model.

Reference

[1]. Evans DM, et al. Exposure time versus cytotoxicity for anticancer agents.Cancer Chemother Pharmacol. 2019 Aug;84(2):359-371.
 [Content Brief]

[2]. Jung M, et al. Targeting BET bromodomains for cancer treatment. Epigenomics. 2015;7(3):487-501.
 [Content Brief]