For research use only. Not for therapeutic Use.
BETA-1 is the first twisted intramolecular charge transfer (TICT)-aggregation-induced emission (AIE) integration molecule. BETA-1 emits cyan fluorescence in lipid droplets (LDs) and red fluorescence in mitochondria. BETA-1 can be used for the simultaneous and dual-color imaging of LDs and mitochondria in vivo and in vitro[1].
BETA-1 can be used for imaging of LDs and Mitochondria in live cells[1].
Wavelength: cyan: λex = 405 nm, λem = 430–500 nm; red: λex = 561 nm, λem = 600–700 nm).
1. HeLa cells were cultured in DMEM supplemented with 10% FBS in a CO2/air (5%/95%) incubator at 37 °C.
2. A total of 5.0 × 103 HeLa cells per well were seeded on a glass-bottom 96-well plate and incubated for 24 h.
3. For cell imaging, live HeLa cells were stained with 5 μM BETA-1 at 37 °C for 30 min.
4. The emission of BETA-1 was collected under excitation at 405 or 561 nm. Digital images were recorded using an laser scanning confocal microscope. The images were analyzed with Fiji/ImageJ.
| Catalog Number | I042363 |
| CAS Number | 2924598-24-1 |
| Synonyms | 4-[(E)-2-(1,3-benzothiazol-2-yl)ethenyl]-N-[4-[(E)-2-(3-methyl-1,3-benzothiazol-3-ium-2-yl)ethenyl]phenyl]-N-phenylaniline;iodide |
| Molecular Formula | C37H28IN3S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C37H28N3S2.HI/c1-39-33-12-6-8-14-35(33)42-37(39)26-20-28-17-23-31(24-18-28)40(29-9-3-2-4-10-29)30-21-15-27(16-22-30)19-25-36-38-32-11-5-7-13-34(32)41-36;/h2-26H,1H3;1H/q+1;/p-1/b25-19+; |
| InChIKey | WADRHSGMGWZVAT-LUINMZRLSA-M |
| SMILES | C[N+]1=C(SC2=CC=CC=C21)C=CC3=CC=C(C=C3)N(C4=CC=CC=C4)C5=CC=C(C=C5)C=CC6=NC7=CC=CC=C7S6.[I-] |
| Reference | [1]. Zeng ST, et al. Construction of a TICT-AIE-Integrated Unimolecular Platform for Imaging Lipid Droplet-Mitochondrion Interactions in Live Cells and In Vivo. ACS Sens. 2022 Dec 19. |
