For research use only. Not for therapeutic Use.
Hydrogen sulfide (H<sub>2</sub>S) is a naturally-<wbr></wbr>occurring gasotransmitter with vasodilator and inflammatory modulating activity. H<sub>2</sub>S is synthesized naturally in a range of mammalian tissues principally by the activity of two enzymes, cystathionine γ lyase (CSE) and cystathionine β synthetase (CBS). β-<wbr></wbr>cyano-<wbr></wbr>L-<wbr></wbr>Alanine (BCA) is a reversible inhibitor of the H<sub>2</sub>S-<wbr></wbr>synthesizing enzyme CSE. BCA blocks H<sub>2</sub>S synthesis in rat liver preparations with an IC<sub>50</sub> value of 6.5 µM and increases blood pressure in anaesthetized rats induced with hemorrhagic shock by inhibiting endogenous H<sub>2</sub>S synthesis. BCA at 50 mg/kg blocked both L-<wbr></wbr>cysteine-<wbr></wbr> and LPS-<wbr></wbr>induced hyperalgesia in rats.
| Catalog Number | R038871 |
| CAS Number | 6232-19-5 |
| Synonyms | BCA |
| Molecular Formula | C4H6N2O2 |
| Purity | ≥95% |
| Target | Endogenous Metabolite |
| Storage | -20°C |
| IUPAC Name | (2S)-2-amino-3-cyanopropanoic acid |
| InChI | InChI=1S/C4H6N2O2/c5-2-1-3(6)4(7)8/h3H,1,6H2,(H,7,8)/t3-/m0/s1 |
| InChIKey | BXRLWGXPSRYJDZ-VKHMYHEASA-N |
| SMILES | C(C#N)C(C(=O)O)N |
