For research use only. Not for therapeutic Use.
Betahistine is a histamine H3 receptor inhibitor with IC50 of 1.9 μM.<br>Betahistine progressively enhances cAMP formation with a maximal effect, observed up to 10 nM, in CHO(H3R) cells incubated with 3 μM forskolin. In contrast, at concentrations higher than 10 nM betahistine progressively inhibits cAMP formation in CHO(H3R) cells incubated with 3 μM forskolin. Betahistine progressively reduces A23187-evoked [<br>Betahistine (< 30 mg/kg) increases t-MeHA levels in a dose-dependent manner with an ED50 of 2 mg/kg and a maximal effect of ∼35% reached at 30 mg/kg in mouse brain.
| Catalog Number | A001166 |
| CAS Number | 5579-84-0 |
| Synonyms | PT-9 |
| Molecular Formula | C8H12N2.2HCl |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | 3 years -20C powder |
