For research use only. Not for therapeutic Use.
Betahistine hydrochloride (Cat. No: I004171), also known as anti-glare, betahistine, is a histamine H1 receptor agonist, belonging to histamine vasodilator drugs, mainly used in the treatment of Meniere’s disease.
| Catalog Number | I004171 |
| CAS Number | 5579-84-0 (HCl) |
| Synonyms | Betahistine dihydrochloride; Betahistine HCl; brand names Veserc, Serc, Hiserk, Betaserc, Vergo.;Methyl[2-(2-pyridyl)ethyl]amine dihydrochloride |
| Molecular Formula | C8H14Cl2N2 |
| Purity | ≥95% |
| Target | H1 receptor agonist |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term or -20 °C for long term |
| IUPAC Name | N-methyl-2-pyridin-2-ylethanamine;dihydrochloride |
| InChI | InChI=1S/C8H12N2.2ClH/c1-9-7-5-8-4-2-3-6-10-8;;/h2-4,6,9H,5,7H2,1H3;2*1H |
| InChIKey | XVDFMHARQUBJRE-UHFFFAOYSA-N |
| SMILES | CNCCC1=CC=CC=N1.Cl.Cl |
| Reference | </br>1:Long-term evaluation of the treatment of Menière/’s disease with betahistine HCl. Bertrand RA.Adv Otorhinolaryngol. 1982;28:104-10. PMID: 7113814 </br>2:Increased coronary collateral blood flow. A possible mechanism of action for betahistine-HCl. Terracio L, Kubicek WG.Acta Anat (Basel). 1979;103(4):461-7. PMID: 442956 </br>3:Modification of the size of developing infarcts in the ligated dog heart by betahistine-HCL. Terracio L, Kubicek WG.Acta Anat (Basel). 1978;101(4):372-9. PMID: 665141 </br>4:Betahistine HCL antagonism upon neural influence on microcirculation. Baez S, Gootman PM, Feldman SM, Orkin LR.Bibl Anat. 1973;12:437-42. No abstract available. PMID: 4208230 </br>5:Méniére/’s disease: subjective and objective evaluation of medical treatment with betahistine HCl. Bertrand RA.Acta Otolaryngol Suppl. 1972;305:48-69. No abstract available. PMID: 4353750 </br>6:Effects of betahistine HCl, nicotinic acid, and histamine on basilar blood flow in anesthetized dogs. Anderson WD, Kubicek WG.Stroke. 1971 Jul-Aug;2(4):409-15. No abstract available. PMID: 5000331 Free Article</br>7:Modification of the vestibular function with betahistine HCl. Bertrand RA.Laryngoscope. 1971 Jun;81(6):889-98. No abstract available. PMID: 4997046 |
