Betamethasone Valerate

• CAT Number: A000941
• CAS Number: 2152-44-5
• Molecular Formula: C27H37FO6
• Molecular Weight: 476.58
• Purity: ≥95%
• Synonyms: Betnovate; Betamethasone 17-valerate; Betaderm; Luxiq; 2152-44-5
• Target: Vitamin D Related/Nuclear Receptor
• Storage: -20°C
• InChI: 1S/C27H37FO6/c1-5-6-7-23(33)34-27(22(32)15-29)16(2)12-20-19-9-8-17-13-18(30)10-11-24(17,3)26(19,28)21(31)14-25(20,27)4/h10-11,13,16,19-21,29,31H,5-9,12,14-15H2,1-4H3/t16-,19-,20-,21-,24-,25-,26-,27-/m0/s1
• InChIKey: SNHRLVCMMWUAJD-SUYDQAKGSA-N
• SMILES: CCCCC(=O)OC1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)C(=O)CO

Betamethasone Valerate is the 17-valerate derivative of Betamethasone. Betamethasone Valerate acts as a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Betamethasone valerate binds to specific intracellular glucocorticoid receptors and subsequently binds to DNA to modify gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited.

Reference

1: Chua SHH, Tioleco GMS, Dayrit CAF, Mojica WP, Dofitas BL, Frez LF.
Atorvastatin as adjunctive therapy for chronic plaque type psoriasis versus
betamethasone valerate alone: A randomized, double-blind, placebo-controlled
trial. Indian J Dermatol Venereol Leprol. 2017 Jul-Aug;83(4):441-447. doi:
10.4103/ijdvl.IJDVL_425_16. PubMed PMID: 28540870.

2: El-Ashmawy AA, El-Maadawy IH, El-Maghraby GM. Efficacy of topical latanoprost
versus minoxidil and betamethasone valerate on the treatment of alopecia areata.
J Dermatolog Treat. 2017 Jun 15:1-10. doi: 10.1080/09546634.2017.1330527. [Epub
ahead of print] PubMed PMID: 28521549.

3: Iraji F, Banihashemi SH, Faghihi G, Shahmoradi Z, Tajmirriahi N, Jazi SB. A
Comparison of Betamethasone Valerate 0.1% Cream Twice Daily Plus Oral Simvastatin
Versus Betamethasone Valerate 0.1% Cream Alone in the Treatment of Vitiligo
Patients. Adv Biomed Res. 2017 Mar 28;6:34. doi: 10.4103/2277-9175.203159.
eCollection 2017. PubMed PMID: 28516068; PubMed Central PMCID: PMC5385703.

4: Fayed AS, Rezk MR, Marzouk HM, Abbas SS. Simultaneous Determination of
Cinchocaine Hydrochloride and Betamethasone Valerate in Presence of Their
Degradation Products. J Chromatogr Sci. 2017 May 1;55(5):518-527. doi:
10.1093/chromsci/bmx004. PubMed PMID: 28168304.

5: Frizziero A, Causero A, Bernasconi S, Papalia R, Longo M, Sessa V, Sadile F,
Greco P, Tarantino U, Masiero S, Rovati S, Frangione V. Efficacy of betamethasone
valerate medicated plaster on painful chronic elbow tendinopathy: a double-blind,
randomized, placebo-controlled trial. Muscles Ligaments Tendons J. 2016 May
19;6(1):131-9. doi: 10.11138/mltj/2016.6.1.131. eCollection 2016 Jan-Mar. PubMed
PMID: 27331041; PubMed Central PMCID: PMC4915452.

6: Solon LG, Lima IP, Nogueira FH, de Araújo JP, Vivacqua CA, Aragão CF.
Development and validation of an UHPLC method for the determination of
betamethasone valerate in cream, gel, ointment and lotion. Steroids. 2016
Feb;106:70-7. doi: 10.1016/j.steroids.2015.12.011. Epub 2015 Dec 18. PubMed PMID:
26708266.

7: Maccari F. Improvement of inflammatory dermatoses severity and quality of life
in patients treated with a betamethasone valerate plaster (LIBERE study). J
Dermatolog Treat. 2016;27(1):59-63. doi: 10.3109/09546634.2015.1035692. Epub 2015
Jun 15. PubMed PMID: 25898980; PubMed Central PMCID: PMC4732425.

8: Lotfy HM, Salem H, Abdelkawy M, Samir A. Spectrophotometric methods for
simultaneous determination of betamethasone valerate and fusidic acid in their
binary mixture. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Apr 5;140:294-304.
doi: 10.1016/j.saa.2014.12.059. Epub 2015 Jan 9. PubMed PMID: 25615682.

9: Chittock J, Brown K, Cork MJ, Danby SG. Comparing the Effect of a Twice-weekly
Tacrolimus and Betamethasone Valerate Dose on the Subclinical Epidermal Barrier
Defect in Atopic Dermatitis. Acta Derm Venereol. 2015 Jul;95(6):653-8. doi:
10.2340/00015555-2048. PubMed PMID: 25594610.

10: Danby SG, Chittock J, Brown K, Albenali LH, Cork MJ. The effect of tacrolimus
compared with betamethasone valerate on the skin barrier in volunteers with
quiescent atopic dermatitis. Br J Dermatol. 2014 Apr;170(4):914-21. doi:
10.1111/bjd.12778. PubMed PMID: 24328907.