Bevonescein

• CAT Number: I041854
• CAS Number: 2276787-79-0
• Molecular Formula: C112H144N22O32
• Molecular Weight: 2310.47
• Purity: ≥95%

Bevonescein (ALM-488) is a novel, intravenously-administrated fluorescein-conjugated peptide that binds nerve-associated connective tissue, labels peripheral nerves under real-time fluorescence imaging (FL) in living mice and human ex vivo nerve tissue. Bevonescein is a peptide-linked tracer which fluorescently labeled both intact and degenerated nerves[1][2].
Bevonescein (ALM-488; 900 nmol; IV; underwent a 90-minute observation period) improves nerve identification for intact, degenerated, and partially regenerated nerves by vivo realtime fluorescence imaging (FL) in female SKH‐1 hairless, wild‐type, ~25 g mice[1].

Reference

[1]. Kayva L Crawford, et al. Identification of Degenerated Murine Facial Nerves With Fluorescence Labeling After Transection Injury. Otolaryngol Head Neck Surg. 2023 Aug;169(2):234-242.
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[2]. Feredun Azari, et al. Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings. J Biomed Opt. 2021 May;26(5):050901. Feredun Azari, et al. Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings. J Biomed Opt. 2021 May;26(5):050901.
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