Bezafibrate 1-O-β-Glucuronide

• CAT Number: C000882
• CAS Number: 72156-77-5
• Molecular Formula: C₂₅H₂₈ClNO₁₀
• Molecular Weight: 537.94
• Purity: ≥95%
• Synonyms: 1-[2-[4-[2-[(4-Chlorobenzoyl)amino]ethyl]phenoxy]-2-methylpropanoate] ?-D-Glucopyranuronic Acid
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Appearance: White to Off-White Solid
• Storage: -20°C, Hygroscopic
• IUPAC Name: (1R,3R,4R,5S,6R)-3-[2-[4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy]-2-methylpropanoyl]oxy-2,4,5,6-tetrahydroxycyclohexane-1-carboxylic acid
• InChI: InChI=1S/C26H30ClNO10/c1-26(2,25(36)37-22-19(30)17(24(34)35)18(29)20(31)21(22)32)38-16-9-3-13(4-10-16)11-12-28-23(33)14-5-7-15(27)8-6-14/h3-10,17-22,29-32H,11-12H2,1-2H3,(H,28,33)(H,34,35)/t17-,18-,19?,20+,21-,22-/m1/s1
• InChIKey: WGEMADLVNCCHDH-QIIRPGIRSA-N
• SMILES: CC(C)(C(=O)OC1C(C(C(C(C1O)O)O)C(=O)O)O)OC2=CC=C(C=C2)CCNC(=O)C3=CC=C(C=C3)Cl

Bezafibrate 1-O-β-Glucuronide (Cat No.:C000882) is a metabolite of bezafibrate, which is a medication used to lower cholesterol and triglyceride levels in the blood. This compound is formed in the body when bezafibrate undergoes glucuronidation, a metabolic process that increases its water solubility and facilitates its excretion. Bezafibrate 1-O-β-Glucuronide is inactive and serves as a means of eliminating the drug from the body. The glucuronidation process is a vital step in the metabolism of drugs, contributing to their pharmacokinetics and detoxification.

Reference

Zimmerman, R., et al.: Atherosclerosis 29, 477 (1978); Abshagen, U., et al.: Eur. J. Clin. Pharmacol., 16, 31 (1979); Monk, J.P., et al.: Drugs, 33, 539 (1987);