BF738735

• CAT Number: I004177
• CAS Number: 1436383-95-7
• Molecular Formula: C21H19FN4O3S
• Molecular Weight: 426.47
• Purity: ≥95%
• Synonyms: BF738735; BF-738735; BF 738735.;2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol
• Target: PI4K; Reverse Transcriptase
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term or -20 °C for long term
• IUPAC Name: 2-fluoro-4-[2-methyl-8-[(3-methylsulfonylphenyl)methylamino]imidazo[1,2-a]pyrazin-3-yl]phenol
• InChI: InChI=1S/C21H19FN4O3S/c1-13-19(15-6-7-18(27)17(22)11-15)26-9-8-23-20(21(26)25-13)24-12-14-4-3-5-16(10-14)30(2,28)29/h3-11,27H,12H2,1-2H3,(H,23,24)
• InChIKey: IMHZCCZYPHJVMS-UHFFFAOYSA-N
• SMILES: CC1=C(N2C=CN=C(C2=N1)NCC3=CC(=CC=C3)S(=O)(=O)C)C4=CC(=C(C=C4)O)F

BF738735（Cat No.:I004177）is a potent and selective inhibitor of Bruton’s tyrosine kinase (BTK), a key enzyme in the B-cell receptor (BCR) signaling pathway that is crucial for B-cell proliferation, differentiation, and survival. By inhibiting BTK, BF738735 blocks downstream signaling cascades, leading to impaired B-cell activation and decreased production of inflammatory cytokines. It is particularly useful in studying autoimmune diseases and B-cell malignancies, including leukemia and lymphoma, where dysregulated BCR signaling plays a role. BF738735 is a valuable tool for investigating BTK-targeted therapies in immunological and oncological research.