For research use only. Not for therapeutic Use.
BF844 is a stabilizer of CLRN1N48K in vitro and in vivo. BF844 effectively attenuated progressive hearing loss and prevented deafness in an Usher syndrome type III (USH3) mouse model.
KEYWORDS: BF844 | supplier | CLRN1-N48K stabilizer | BF-844 | BF 844 | CAS [1404506-35-9] | CLRN | Stabilizer
| Catalog Number | I023318 |
| CAS Number | 1404506-35-9 |
| Molecular Formula | C21H19ClN4O |
| Purity | ≥95% |
| IUPAC Name | 1-(4-chloro-3,5-diphenylpyrazolo[3,4-c]pyridazin-1-yl)-2-methylpropan-2-ol |
| InChI | InChI=1S/C21H19ClN4O/c1-21(2,27)13-26-20-16(18(25-26)14-9-5-3-6-10-14)17(22)19(23-24-20)15-11-7-4-8-12-15/h3-12,27H,13H2,1-2H3 |
| SMILES | CC(C)(CN1C2=NN=C(C(=C2C(=N1)C3=CC=CC=C3)Cl)C4=CC=CC=C4)O |
| Reference | KN Alagramam et al. A small molecule mitigates hearing loss in a mouse model of Usher syndrome III. Nat Chem Biol. 2016 Jun;12(6):444-51. |
