For research use only. Not for therapeutic Use.
BGN3 is a good substrate for the SNAP-tag? and H5 enzymes. The activities of SNAP-tag? and H5 enzymes on BGN3 are reasonable (IC50= 15.6 and 23.5 μM, respectively)[1]. BGN3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
Substrate specificity of SNAP-tag® and H5 by competitive inhibition method (IC50) by using SVG as substrate[1].
| Catalog Number | I044442 |
| CAS Number | 1151762-33-2 |
| Synonyms | 6-[[4-(azidomethyl)phenyl]methoxy]-7H-purin-2-amine |
| Molecular Formula | C13H12N8O |
| Purity | ≥95% |
| InChI | InChI=1S/C13H12N8O/c14-13-19-11-10(16-7-17-11)12(20-13)22-6-9-3-1-8(2-4-9)5-18-21-15/h1-4,7H,5-6H2,(H3,14,16,17,19,20) |
| InChIKey | DSPWEULBEPDTGO-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1CN=[N+]=[N-])COC2=NC(=NC3=C2NC=N3)N |
| Reference | [1]. Merlo R, et al. The SNAP-tag technology revised: an effective chemo-enzymatic approach by using a universal azide-based substrate. J Enzyme Inhib Med Chem. 2021;36(1):85-97. |
