BI-1347

• CAT Number: I019027
• CAS Number: 2163056-91-3
• Molecular Formula: C₂₂H₂₀N₄O
• Molecular Weight: 356.42
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 2-[4-(4-isoquinolin-4-ylphenyl)pyrazol-1-yl]-N,N-dimethylacetamide
• InChI: InChI=1S/C22H20N4O/c1-25(2)22(27)15-26-14-19(12-24-26)16-7-9-17(10-8-16)21-13-23-11-18-5-3-4-6-20(18)21/h3-14H,15H2,1-2H3
• InChIKey: WULUGQONDYDNKY-UHFFFAOYSA-N
• SMILES: CN(C)C(=O)CN1C=C(C=N1)C2=CC=C(C=C2)C3=CN=CC4=CC=CC=C43

BI-1347（Cat No.:I019027）is a potent small molecule inhibitor specifically targeting Cyclin-dependent kinase 8 (CDK8). With an impressive IC50 value of 1.1 nM, BI-1347 effectively inhibits the enzymatic activity of CDK8, a crucial regulator of gene transcription and cell cycle progression. By selectively targeting CDK8, BI-1347 has the potential to modulate various cellular processes and signaling pathways. It’s high potency and specificity makes it a promising candidate for therapeutic interventions, particularly in diseases where dysregulated CDK8 activity plays a significant role.

Reference

[1]. Harald Engelhardt, et al. New phenylpyrazolylacetamide compounds and derivatives as cdk8/cdk19 inhibitors.