For research use only. Not for therapeutic Use.
BI-167107 is a high affinity, full agonist that binds to the β2 adrenergic receptor (β2AR) with a dissociation constant Kd of 84 pM[1].
Compared to other βAR ligands, BI-167107 displays nanomolar affinities and slow off-rates[1].
| Catalog Number | I017968 |
| CAS Number | 1202235-68-4 |
| Synonyms | 5-hydroxy-8-[1-hydroxy-2-[[2-methyl-1-(2-methylphenyl)propan-2-yl]amino]ethyl]-4H-1,4-benzoxazin-3-one |
| Molecular Formula | C21H26N2O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H26N2O4/c1-13-6-4-5-7-14(13)10-21(2,3)22-11-17(25)15-8-9-16(24)19-20(15)27-12-18(26)23-19/h4-9,17,22,24-25H,10-12H2,1-3H3,(H,23,26) |
| InChIKey | NWQXBEWHTDRJIP-UHFFFAOYSA-N |
| SMILES | CC1=CC=CC=C1CC(C)(C)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O |
| Reference | [1]. Rasmussen SG, et al. Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature. 2011 Jan 13;469(7329):175-80. |
