BI-3812

• CAT Number: I020107
• CAS Number: 2166387-64-8
• Molecular Formula: C₂₆H₃₂ClN₇O₅
• Molecular Weight: 558.03
• Purity: ≥95%
• Target: Bcl-2 Family
• Storage: Store at -20°C
• IUPAC Name: 1-[5-chloro-4-[[8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxoquinolin-6-yl]amino]pyrimidin-2-yl]-N,N-dimethylpiperidine-4-carboxamide
• InChI: InChI=1S/C26H32ClN7O5/c1-28-21(35)14-39-20-11-16-10-17(12-19(38-5)22(16)33(4)25(20)37)30-23-18(27)13-29-26(31-23)34-8-6-15(7-9-34)24(36)32(2)3/h10-13,15H,6-9,14H2,1-5H3,(H,28,35)(H,29,30,31)
• InChIKey: XCGYXEVLQIIEJH-UHFFFAOYSA-N
• SMILES: CNC(=O)COC1=CC2=CC(=CC(=C2N(C1=O)C)OC)NC3=NC(=NC=C3Cl)N4CCC(CC4)C(=O)N(C)C

BI-3812（Cat No.:I020107） is a potent and selective inhibitor of the B-cell lymphoma 6 (BCL6) protein. It binds to the BTB domain of BCL6 and induces the degradation of the protein, leading to the inhibition of BCL6-dependent transcriptional repression. BI-3812 has shown antitumor activity in various preclinical cancer models, including diffuse large B-cell lymphoma, mantle-cell lymphoma, and multiple myeloma.