For research use only. Not for therapeutic Use.
BI-4142（Cat No.:I043353）is a potent and selective inhibitor of the protein kinase LRRK2 (leucine-rich repeat kinase 2), which has been implicated in the pathogenesis of Parkinson’s disease. By inhibiting LRRK2, BI-4142 aims to modulate cellular pathways involved in neurodegeneration, particularly those related to dopaminergic neurons. It has shown potential in preclinical studies for reducing inflammation and improving cellular function in Parkinson’s disease models. BI-4142 represents a promising therapeutic strategy for treating Parkinson’s disease, especially in cases associated with LRRK2 mutations, and is under investigation for its safety and efficacy in clinical trials.
| CAS Number | 2682003-36-5 |
| Synonyms | 1-[4-[4-[3-methyl-4-(1-methylbenzimidazol-5-yl)oxyanilino]pyrimido[5,4-d]pyrimidin-6-yl]piperazin-1-yl]prop-2-en-1-one |
| Molecular Formula | C28H27N9O2 |
| Purity | ≥95% |
| IUPAC Name | 1-[4-[4-[3-methyl-4-(1-methylbenzimidazol-5-yl)oxyanilino]pyrimido[5,4-d]pyrimidin-6-yl]piperazin-1-yl]prop-2-en-1-one |
| InChI | InChI=1S/C28H27N9O2/c1-4-25(38)36-9-11-37(12-10-36)28-29-15-22-26(34-28)27(31-16-30-22)33-19-5-8-24(18(2)13-19)39-20-6-7-23-21(14-20)32-17-35(23)3/h4-8,13-17H,1,9-12H2,2-3H3,(H,30,31,33) |
| InChIKey | JKBYBPNRTMHEGS-UHFFFAOYSA-N |
| SMILES | CC1=C(C=CC(=C1)NC2=NC=NC3=CN=C(N=C32)N4CCN(CC4)C(=O)C=C)OC5=CC6=C(C=C5)N(C=N6)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
