For research use only. Not for therapeutic Use.
BI6015 is a small molecule antagonist of Hepatocyte nuclear factor 4α (HNF4α) that has been shown to repress the expression of known HNF4α target genes.
| CAS Number | 93987-29-2 |
| Synonyms | 2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole; 2-Methyl-1-[(5-nitro-o-tolyl)sulfonyl]-benzimidazole; |
| Molecular Formula | C15H13N3O4S |
| Purity | ≥95% |
| Target | Transcription Factors |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | Store at -20C |
| IUPAC Name | 2-methyl-1-(2-methyl-5-nitrophenyl)sulfonylbenzimidazole |
| InChI | InChI=1S/C15H13N3O4S/c1-10-7-8-12(18(19)20)9-15(10)23(21,22)17-11(2)16-13-5-3-4-6-14(13)17/h3-9H,1-2H3 |
| InChIKey | ILVCPQPMRPHZSG-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N2C(=NC3=CC=CC=C32)C |
| Reference | </br>1: Mayati A, Le Vee M, Moreau A, Jouan E, Bucher S, Stieger B, Denizot C, Parmentier Y, Fardel O. Protein kinase C-dependent regulation of human hepatic drug transporter expression. Biochem Pharmacol. 2015 Dec 15;98(4):703-17. doi: 10.1016/j.bcp.2015.10.007. PubMed PMID: 26462574.</br>2: Kiselyuk A, Lee SH, Farber-Katz S, Zhang M, Athavankar S, Cohen T, Pinkerton AB, Ye M, Bushway P, Richardson AD, Hostetler HA, Rodriguez-Lee M, Huang L, Spangler B, Smith L, Higginbotham J, Cashman J, Freeze H, Itkin-Ansari P, Dawson MI, Schroeder F, Cang Y, Mercola M, Levine F. HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem Biol. 2012 Jul 27;19(7):806-18. doi: 10.1016/j.chembiol.2012.05.014. PubMed PMID: 22840769; PubMed Central PMCID: PMC3447631.</br></br> |
