BI 689648

• CAT Number: I013079
• CAS Number: 1633009-87-6
• Molecular Formula: C₁₆H₁₈N₄O₂
• Molecular Weight: 298.34
• Purity: ≥95%
• Target: Cytochrome P450
• Solubility: DMSO: 30 mg/mL
• IUPAC Name: 6-[5-(methoxymethyl)pyridin-3-yl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide
• InChI: InChI=1S/C16H18N4O2/c1-22-10-11-5-13(8-18-7-11)14-6-12-3-2-4-20(16(17)21)15(12)19-9-14/h5-9H,2-4,10H2,1H3,(H2,17,21)
• InChIKey: DJFDCVNQDFICKV-UHFFFAOYSA-N
• SMILES: COCC1=CN=CC(=C1)C2=CC3=C(N=C2)N(CCC3)C(=O)N

BI 689648(CAT: I013079) is a novel and highly selective inhibitor of aldosterone synthase (CYP11B2), an enzyme critical for aldosterone biosynthesis. It exhibits an IC₅₀ of 2.1 nM for CYP11B2 while maintaining significantly less activity against 11β-hydroxylase (CYP11B1), with an IC₅₀ of 310 nM. This selectivity makes BI 689648 particularly valuable in cardiovascular and endocrine research, supporting studies on conditions such as hypertension, heart failure, and primary aldosteronism. By inhibiting aldosterone production, it helps explore therapeutic strategies targeting aldosterone-mediated pathologies. BI 689648 is a powerful tool for advancing drug discovery and understanding aldosterone’s role in disease progression.