BI-6C9

• CAT Number: R065495
• CAS Number: 791835-21-7
• Molecular Formula: C23H25N3O4S2
• Molecular Weight: 471.59
• Purity: ≥95%
• Synonyms: N-[4-[(4-aminophenyl)thio]phenyl]-4-[[(4-methoxyphenyl)sulfonyl]amino]-butanamide
• Storage: -20°C
• IUPAC Name: N-[4-(4-aminophenyl)sulfanylphenyl]-4-[(4-methoxyphenyl)sulfonylamino]butanamide
• InChI: InChI=1S/C23H25N3O4S2/c1-30-19-8-14-22(15-9-19)32(28,29)25-16-2-3-23(27)26-18-6-12-21(13-7-18)31-20-10-4-17(24)5-11-20/h4-15,25H,2-3,16,24H2,1H3,(H,26,27)
• InChIKey: LCFUJBSKPDPGKO-UHFFFAOYSA-N
• SMILES: COC1=CC=C(C=C1)S(=O)(=O)NCCCC(=O)NC2=CC=C(C=C2)SC3=CC=C(C=C3)N

BI-6C9（Cat No.:R065495）is a selective inhibitor of the anti-apoptotic protein Bcl-2-associated athanogene 1 (BAG1), which modulates cell survival by interacting with Bcl-2 family proteins. By inhibiting BAG1, BI-6C9 disrupts the protein’s protective effects, sensitizing cells to apoptosis, particularly in cancer cells that overexpress BAG1 for survival. This compound is valuable in cancer research, as it allows the exploration of apoptosis pathways and the role of BAG1 in tumor cell resistance to therapy. BI-6C9 serves as a potential tool in developing treatments targeting apoptotic resistance mechanisms in oncology.

Reference

1.Dejean, L.M.,Ryu, S.Y.,Martinez-Caballero, S., et al. MAC and Bcl-2 family proteins conspire in a deadly plot. Biochimica et Biophysica Acta 1797(6-7), 1231-1238 (2010).