BI8626

For research use only. Not for therapeutic Use.

  • CAT Number: I019184
  • CAS Number: 1875036-75-1
  • Molecular Formula: C₂₅H₂₈N₈
  • Molecular Weight: 440.54
  • Purity: ≥95%
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BI8626(CAT: I019184) is a specific inhibitor of the ubiquitin ligase HUWE1, widely used in cellular and molecular biology research. HUWE1 plays a critical role in protein homeostasis by regulating the ubiquitination of key substrates involved in apoptosis, DNA damage response, and cell cycle control. BI8626 enables researchers to study the functional role of HUWE1 in various cellular processes and its implications in diseases such as cancer and neurodegeneration. With its high specificity and effectiveness, BI8626 is a valuable tool for advancing our understanding of ubiquitin-proteasome system regulation and exploring therapeutic opportunities targeting HUWE1.


Catalog Number I019184
CAS Number 1875036-75-1
Molecular Formula C₂₅H₂₈N₈
Purity ≥95%
Target E1/E2/E3 Enzyme
IUPAC Name N-[[3-(aminomethyl)phenyl]methyl]-4-(4-benzylpiperazin-1-yl)pyrimido[5,4-d]pyrimidin-8-amine
InChI InChI=1S/C25H28N8/c26-14-20-7-4-8-21(13-20)15-27-24-22-23(29-17-30-24)25(31-18-28-22)33-11-9-32(10-12-33)16-19-5-2-1-3-6-19/h1-8,13,17-18H,9-12,14-16,26H2,(H,27,29,30)
InChIKey DZDNGSNKWIORRZ-UHFFFAOYSA-N
SMILES C1CN(CCN1CC2=CC=CC=C2)C3=NC=NC4=C3N=CN=C4NCC5=CC=CC(=C5)CN

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