BI8626

For research use only. Not for therapeutic Use.

  • CAT Number: I019184
  • CAS Number: 1875036-75-1
  • Molecular Formula: C₂₅H₂₈N₈
  • Molecular Weight: 440.54
  • Purity: ≥95%
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BI8626 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 0.9 μM[1].<br>BI8626 induces HUWE1 ectopically expresses to abolishe ubiquitination of MCL1 in HeLa cells[1].
BI8626 suppresses colony formation of Ls174T cells with estimated IC50 value of 0.7 μM, and BI8622 (1-4 days) treatment retards passage of Ls174T cells through all phases of the cell cycle, with the effect being strongest for G1[1].
BI8626 (0-50 μM; 0-6 hours) retards the degradation of MCL1 in response to UV irradiation to the same extent as depletion of HUWE1 in U2OS cells[1].


Catalog Number I019184
CAS Number 1875036-75-1
Molecular Formula C₂₅H₂₈N₈
Purity ≥95%
Target E1/E2/E3 Enzyme
Reference

[1]. Peter S, et al. Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase.EMBO Mol Med. 2014 Dec;6(12):1525-41.

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