For research use only, not for therapeutic use.
BIBR 1532（Cat No.:I003146）is a selective and potent inhibitor of telomerase, an enzyme responsible for maintaining telomere length, which plays a crucial role in cellular immortality and cancer progression. By inhibiting telomerase activity, BIBR 1532 promotes telomere shortening, leading to cellular senescence and apoptosis in rapidly dividing cancer cells. This compound is extensively studied in oncology research as a potential therapeutic strategy for targeting telomerase in tumors. Its specificity for telomerase makes it a valuable tool for understanding telomere biology and developing novel anticancer treatments.
| Catalog Number | I003146 |
| CAS Number | 321674-73-1 |
| Synonyms | 2-[[(E)-3-naphthalen-2-ylbut-2-enoyl]amino]benzoic acid |
| Molecular Formula | C21H17NO3 |
| Purity | ≥95% |
| Target | Telomerase |
| Solubility | DMSO: 66 mg/mL, H2O: <1 mg/mL |
| Storage | 3 years -20C powder |
| IC50 | 100 nM |
| IUPAC Name | 2-[[(E)-3-naphthalen-2-ylbut-2-enoyl]amino]benzoic acid |
| InChI | InChI=1S/C21H17NO3/c1-14(16-11-10-15-6-2-3-7-17(15)13-16)12-20(23)22-19-9-5-4-8-18(19)21(24)25/h2-13H,1H3,(H,22,23)(H,24,25)/b14-12+ |
| InChIKey | PGFQXGLPJUCTOI-WYMLVPIESA-N |
| SMILES | C/C(=C\C(=O)NC1=CC=CC=C1C(=O)O)/C2=CC3=CC=CC=C3C=C2 |
| Reference | </br>1:Glucose restriction decreases telomerase activity and enhances its inhibitor response on breast cancer cells: possible extra-telomerase role of BIBR 1532. Wardi L, Alaaeddine N, Raad I, Sarkis R, Serhal R, Khalil C, Hilal G.Cancer Cell Int. 2014 Jul 4;14:60. doi: 10.1186/1475-2867-14-60. eCollection 2014. PMID: 25089119 Free PMC Article</br>2:BIBR 1532 increases arsenic trioxide-mediated apoptosis in acute promyelocytic leukemia cells: therapeutic potential for APL. Bashash D, Ghaffari SH, Zaker F, Kazerani M, Hezave K, Hassani S, Rostami M, Alimoghaddam K, Ghavamzadeh A.Anticancer Agents Med Chem. 2013 Sep;13(7):1115-25. PMID: 23293885 </br>3:Direct short-term cytotoxic effects of BIBR 1532 on acute promyelocytic leukemia cells through induction of p21 coupled with downregulation of c-Myc and hTERT transcription. Bashash D, Ghaffari SH, Zaker F, Hezave K, Kazerani M, Ghavamzadeh A, Alimoghaddam K, Mosavi SA, Gharehbaghian A, Vossough P.Cancer Invest. 2012 Jan;30(1):57-64. doi: 10.3109/07357907.2011.629378. PMID: 22236190 </br>4:Inhibition of telomerase by BIBR 1532 and related analogues. Barma DK, Elayadi A, Falck JR, Corey DR.Bioorg Med Chem Lett. 2003 Apr 7;13(7):1333-6. PMID: 12657276 |
