BIIL-260 hydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: I018171
  • CAS Number: 192581-24-1
  • Molecular Formula: C30H31ClN2O3
  • Molecular Weight: 503.03
  • Purity: ≥95%
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BIIL-260 hydrochloride is a potent and long-acting orally active leukotriene B(4) receptor LTB4 antagonist, with anti-inflammatory activity. BIIL-260 hydrochloride interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB4 receptor on isolated human neutrophil cell membranes with Ki values of 1.7 nM[1].
BIIL-260 hydrochloride potently inhibits LTB4-induced intracellular Ca2+ release in human neutrophils with IC50 value of 0.82 nM


Catalog Number I018171
CAS Number 192581-24-1
Synonyms

4-[[3-[[4-[2-(4-hydroxyphenyl)propan-2-yl]phenoxy]methyl]phenyl]methoxy]benzenecarboximidamide;hydrochloride

Molecular Formula C30H31ClN2O3
Purity ≥95%
InChI InChI=1S/C30H30N2O3.ClH/c1-30(2,24-8-12-26(33)13-9-24)25-10-16-28(17-11-25)35-20-22-5-3-4-21(18-22)19-34-27-14-6-23(7-15-27)29(31)32;/h3-18,33H,19-20H2,1-2H3,(H3,31,32);1H
InChIKey KYFHIWXKXUSXKB-UHFFFAOYSA-N
SMILES CC(C)(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCC3=CC=CC(=C3)COC4=CC=C(C=C4)C(=N)N.Cl
Reference

[1]. Birke FW, et al. In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist. J Pharmacol Exp Ther. 2001 Apr;297(1):458-66.
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