Bim-IN-1

• CAT Number: I044124
• CAS Number: 2909483-36-7
• Molecular Formula: C19H20Cl2FNO2S
• Molecular Weight: 416.34
• Purity: ≥95%
• Synonyms: 1-[(2,4-dichlorophenyl)methylsulfonyl]-2-(3-fluorophenyl)azepane
• InChI: InChI=1S/C19H20Cl2FNO2S/c20-16-9-8-15(18(21)12-16)13-26(24,25)23-10-3-1-2-7-19(23)14-5-4-6-17(22)11-14/h4-6,8-9,11-12,19H,1-3,7,10,13H2
• InChIKey: SFVNBTZMJWQDLM-UHFFFAOYSA-N
• SMILES: C1CCC(N(CC1)S(=O)(=O)CC2=C(C=C(C=C2)Cl)Cl)C3=CC(=CC=C3)F

Bim-IN-1 is a potent Bim expression inhibitor. Bim-IN-1 reduces Bim expression levels and has little inhibitory effect upon protein kinase A activity and minimal toxicity[1].
Bim-IN-1 (compound 63, mouse embryonic fibroblasts; 0, 25, 50 μM; 72 hours) demonstrates strong reduction of Bim expression levels at a low micromolar level with low toxicity[1].

Reference

[1]. Richards BJ, et al. Discovery, synthesis and exploration of N-benzylsulfonyl-2-phenylazepanes as inhibitors of Bim expression in a mouse embryonic fibroblast model. Bioorg Chem. 2022; 120:105635.
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