For research use only. Not for therapeutic Use.
Binedaline, also known as Scha-1059, Ixprim, binodaline, is a drug that was being investigated as an antidepressant in the 1980s but never marketed. It acts as a selective norepinephrine reuptake inhibitor (Ki = 25 nM), with relatively insignificant influence on the serotonin (Ki = 847 nM) and dopamine (Ki >= 2 µM) transporters. It has negligible affinity for the α-adrenergic, mACh, H1, or 5-HT2 receptors.
| Catalog Number | R031923 |
| CAS Number | 60662-16-0 |
| Synonyms | N1,N1,N2-Trimethyl-N2-(3-phenyl-1H-indol-1-yl)-1,2-ethanediamine; N,N,N’-Trimethyl-N’-(3-phenyl-1H-indol-1-yl)-1,2-ethanediamine; Binodaline? |
| Molecular Formula | C19H23N3 |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | N,N,N/'-trimethyl-N/'-(3-phenylindol-1-yl)ethane-1,2-diamine |
| InChI | InChI=1S/C19H23N3/c1-20(2)13-14-21(3)22-15-18(16-9-5-4-6-10-16)17-11-7-8-12-19(17)22/h4-12,15H,13-14H2,1-3H3 |
| InChIKey | SXYFFMXPDDGOEK-UHFFFAOYSA-N |
| SMILES | CN(C)CCN(C)N1C=C(C2=CC=CC=C21)C3=CC=CC=C3 |
| Reference | </br>1:Pharmacological profile of binedaline, a new antidepressant drug. Morin D, Zini R, Urien S, Tillement JP.J Pharmacol Exp Ther. 1989 Apr;249(1):288-96. PMID: 2540319 </br>2:Acute effects on psychomotor performance of binedaline alone and with alcohol. Patat A, Klein MJ, Jones RW.Methods Find Exp Clin Pharmacol. 1988 Jun;10(6):393-9. PMID: 3412049 </br>3:Inhibition of binedaline binding to human alpha 1-acid glycoprotein and other serum proteins by chlorpromazine, imipramine, and propranolol. Morin D, Zini R, Ledewyn S, Tillement JP.J Pharm Sci. 1986 Sep;75(9):883-5. PMID: 3783457 </br>4:Human cognitive function following binedaline (50 mg and 100 mg) and imipramine (75 mg): results with a new battery on tests. Jones DM, Allen EM, Griffiths AN, Marshall RW, Richens A.Psychopharmacology (Berl). 1986;89(2):198-202. PMID: 3088636 </br>5:Binedaline binding to plasma proteins and red blood cells in humans. Morin D, Zini R, Ledewyn S, Colonna JP, Czajka M, Tillement JP.J Pharm Sci. 1985 Jul;74(7):727-30. PMID: 4032243 </br>6:A comparison of the cardiovascular effects and subjective tolerability of binedaline and amitriptylene in healthy volunteers. Joubert PH, Starke DD, Van Reenen O, Venter CP.Eur J Clin Pharmacol. 1985;27(6):667-70. PMID: 3886394 </br>7:A controlled double-blind study comparing binedaline and imipramine in the treatment of endogenous depression. Faltus F, Geerling FC.Neuropsychobiology. 1984;12(1):34-8. PMID: 6239991 |
