BIO-013077-01

• CAT Number: I015553
• CAS Number: 746667-48-1
• Molecular Formula: C17H13N5
• Molecular Weight: 287.32
• Purity: ≥95%
• Synonyms: 6-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoxaline
• InChI: InChI=1S/C17H13N5/c1-11-3-2-4-15(21-11)17-13(10-20-22-17)12-5-6-14-16(9-12)19-8-7-18-14/h2-10H,1H3,(H,20,22)
• InChIKey: VXJLYXCHOKEODY-UHFFFAOYSA-N
• SMILES: CC1=NC(=CC=C1)C2=C(C=NN2)C3=CC4=NC=CN=C4C=C3

BIO-013077-01 is a pyrazole TGF-β inhibitor[1].
A wide range of cellular functions such as cell proliferation, differentiation, adhesion, migration, and apoptosis are regulated by TGF-β superfamily members. The TGF-βs include the three major TGF-β isoforms, TGF-β1, TGF-β2, and TGF-β3 which are expressed in mammals. TGF-β transduces signals through a complex of two related but structurally and functionally distinct serine/threonine kinase receptors, termed type 1 and type II. Deregulation of TGF-β signaling has been also implicated in various human diseases including cancer, pancreatic diseases, and hematological malignancies[1].

Reference

[1]. Jin CH, et al. Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors. Eur J Med Chem. 2011 Sep;46(9):3917-25.
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