BIO 5192

• CAT Number: I011087
• CAS Number: 327613-57-0
• Molecular Formula: C38H46Cl2N6O8S
• Molecular Weight: 817.78
• Purity: ≥95%
• Synonyms: (2S)-2-[[[(2S)-1-[(3,5-Dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl]amino]butanoic acid
• Target: Integrin
• Solubility: Soluble to 100 mM in DMSO and to 50 mM in 1eq. NaOH
• Storage: Store at -20°C
• IUPAC Name: (2S)-2-[[(2S)-1-(3,5-dichlorophenyl)sulfonylpyrrolidine-2-carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl-[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]amino]pentanoyl]amino]butanoic acid
• InChI: InChI=1S/C38H46Cl2N6O8S/c1-23(2)18-33(45(4)34(47)19-25-11-13-28(14-12-25)42-38(52)44-30-9-6-5-8-24(30)3)35(48)41-16-15-31(37(50)51)43-36(49)32-10-7-17-46(32)55(53,54)29-21-26(39)20-27(40)22-29/h5-6,8-9,11-14,20-23,31-33H,7,10,15-19H2,1-4H3,(H,41,48)(H,43,49)(H,50,51)(H2,42,44,52)/t31-,32-,33-/m0/s1
• InChIKey: MNQBPRHHZPXCKZ-ZDCRTTOTSA-N
• SMILES: CC1=CC=CC=C1NC(=O)NC2=CC=C(C=C2)CC(=O)N(C)C(CC(C)C)C(=O)NCCC(C(=O)O)NC(=O)C3CCCN3S(=O)(=O)C4=CC(=CC(=C4)Cl)Cl

BIO 5192 (Cat.No:I011087) is a potent and selective inhibitor of BRD4, a bromodomain-containing protein that plays a role in gene transcription regulation. It binds to the BRD4 bromodomain with high affinity, leading to inhibition of BRD4-mediated transcription and cell growth. BIO 5192 has been shown to have antiproliferative effects in a variety of cancer cell lines and to suppress tumor growth in animal models. It is currently being investigated as a potential therapeutic agent for cancer.