For research use only. Not for therapeutic Use.
Bio-AMS(CAT: I040958) is a potent inhibitor of bacterial biotin protein ligase, exhibiting selective activity against Mycobacterium tuberculosis (Mtb). By inhibiting this enzyme, Bio-AMS disrupts fatty acid and lipid biosynthesis, essential processes for Mtb survival. It has demonstrated significant antitubercular activity against both drug-sensitive and multidrug-resistant Mtb strains, with minimum inhibitory concentrations (MICs) ranging from 0.16 to 0.625 μM. Notably, Bio-AMS’s efficacy is not influenced by variations in primary carbon sources. In studies involving Mtb-infected mouse macrophages, Bio-AMS inhibited bacterial growth in a concentration-dependent manner without exhibiting mitochondrial toxicity. These properties make Bio-AMS a valuable tool for tuberculosis research and the development of novel antimicrobial therapies.
| Catalog Number | I040958 |
| CAS Number | 1393881-52-1 |
| Synonyms | 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfamoyl]pentanamide |
| Molecular Formula | C20H29N9O7S2 |
| Purity | ≥95% |
| IUPAC Name | 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfamoyl]pentanamide |
| InChI | InChI=1S/C20H29N9O7S2/c21-17-14-18(23-7-22-17)29(8-24-14)19-16(32)15(31)10(36-19)5-25-38(34,35)28-12(30)4-2-1-3-11-13-9(6-37-11)26-20(33)27-13/h7-11,13,15-16,19,25,31-32H,1-6H2,(H,28,30)(H2,21,22,23)(H2,26,27,33)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 |
| InChIKey | RSZBCKJLQVSFKT-RHCAYAJFSA-N |
| SMILES | C1[C@H]2[C@@H]([C@@H](S1)CCCCC(=O)NS(=O)(=O)NC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)O)O)NC(=O)N2 |
