BioE-1115

• CAT Number: I017781
• CAS Number: 1268863-35-9
• Molecular Formula: C₁₉H₁₈FN₃O₂
• Molecular Weight: 339.36
• Purity: ≥95%
• Target: Cell Cycle/DNA Damage
• IUPAC Name: 2-(4-fluorophenyl)-3-[methyl(propan-2-yl)amino]quinoxaline-6-carboxylic acid
• InChI: InChI=1S/C19H18FN3O2/c1-11(2)23(3)18-17(12-4-7-14(20)8-5-12)21-15-9-6-13(19(24)25)10-16(15)22-18/h4-11H,1-3H3,(H,24,25)
• InChIKey: JKKRYYTVQXUOKL-UHFFFAOYSA-N
• SMILES: CC(C)N(C)C1=NC2=C(C=CC(=C2)C(=O)O)N=C1C3=CC=C(C=C3)F

BioE-1115 (Cat No.:I017781) is a highly selective and potent inhibitor of PAS kinase (PASK) and casein kinase 2α. It exhibits an IC50 of approximately 4 nM against PASK and around 10 μM against casein kinase 2α. In cellular studies, BioE-1115 reduces PASK phosphorylation and suppresses SREBP activity, a key regulator of lipid metabolism, in a dose-dependent manner. Animal studies demonstrate that BioE-1115 administration leads to the suppression of SREBP-1c target genes, decreased insulin resistance, hepatic and serum triglycerides, and serum glucose levels. BioE-1115 shows potential as a therapeutic agent for conditions involving dysregulated lipid metabolism and insulin resistance.

Reference

[1]. Wu X, et al. PAS kinase drives lipogenesis through SREBP-1 maturation. Cell Rep. 2014 Jul 10;8(1):242-55.