For research use only. Not for therapeutic Use.
Biotin alkyne (Cat No.: I023404) is a biotin derivative containing an alkyne functional group, making it a valuable tool in bioconjugation and click chemistry applications. It is widely used in labeling, affinity purification, and protein interaction studies due to biotin’s strong binding affinity for streptavidin. The alkyne group enables selective conjugation with azide-containing molecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC), facilitating precise modifications in biochemical research. Biotin alkyne is essential in proteomics, molecular imaging, and targeted drug delivery studies.
| CAS Number | 773888-45-2 |
| Molecular Formula | C13H19N3O2S |
| Purity | 98% |
| Target | PROTAC Linkers |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(prop-2-yn-1-yl)pentanamide |
| InChI | InChI=1S/C13H19N3O2S/c1-2-7-14-11(17)6-4-3-5-10-12-9(8-19-10)15-13(18)16-12/h1,9-10,12H,3-8H2,(H,14,17)(H2,15,16,18)/t9-,10-,12-/m0/s1 |
| InChIKey | JJXUHRONZVELPY-NHCYSSNCSA-N |
| SMILES | O=C1N[C@@]2([H])[C@@](CS[C@H]2CCCCC(NCC#C)=O)([H])N1 |
| Reference | 1. Rink, W.M.; Thomas, F. Decoration of Coiled-Coil Peptides with N-Cysteine Peptide Thioesters As Cyclic Peptide Precursors Using Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC) Click Reaction. Organic Letters, 2018, 20(23), 7493–7497. doi: 10.1021/acs.orglett.8b03261 |
