Biotin-C5-Azide

• CAT Number: I042596
• CAS Number: 1260586-88-6
• Molecular Formula: C10H17N5OS
• Molecular Weight: 255.34
• Purity: ≥95%
• Synonyms: (3aS,4S,6aR)-4-(5-azidopentyl)-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-2-one
• InChI: InChI=1S/C10H17N5OS/c11-15-12-5-3-1-2-4-8-9-7(6-17-8)13-10(16)14-9/h7-9H,1-6H2,(H2,13,14,16)/t7-,8-,9-/m0/s1
• InChIKey: CSDCRNNAOYVBRW-CIUDSAMLSA-N
• SMILES: C1C2C(C(S1)CCCCCN=[N+]=[N-])NC(=O)N2

Biotin-C5-Azide (DecarboxyBiotin-N3) is a biotin reagent and can be used to prepare biotinylated conjugates[1]. Biotin-C5-Azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Reference

[1]. Pfaff P, et al. Azoacetylenes for the Synthesis of Arylazotriazole Photoswitches. J Am Chem Soc. 2021 Sep 15;143(36):14495-14501.
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