(+)-Biotin-ONP

• CAT Number: I016323
• CAS Number: 33755-53-2
• Molecular Formula: C₁₆H₁₉N₃O₅S
• Molecular Weight: 365.4
• Purity: ≥95%
• Target: PROTAC Linkers
• Storage: Room Temperature
• IUPAC Name: (4-nitrophenyl) 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoate
• InChI: InChI=1S/C16H19N3O5S/c20-14(24-11-7-5-10(6-8-11)19(22)23)4-2-1-3-13-15-12(9-25-13)17-16(21)18-15/h5-8,12-13,15H,1-4,9H2,(H2,17,18,21)/t12-,13-,15-/m0/s1
• InChIKey: YUDNXDTXQPYKCA-YDHLFZDLSA-N
• SMILES: C1C2C(C(S1)CCCCC(=O)OC3=CC=C(C=C3)[N+](=O)[O-])NC(=O)N2

(+)-Biotin-ONP（Cat No.:I016323） is an alkyl chain-based linker commonly used in the synthesis of proteolysis-targeting chimera (PROTAC) molecules. This linker incorporates a biotin moiety, which offers affinity for avidin or streptavidin-based capture systems, aiding in the purification and isolation of PROTAC conjugates. (+)-Biotin-ONP enables the conjugation of target protein binders, such as small molecules or antibodies, to the E3 ligase ligand, facilitating the targeted degradation of specific proteins. The versatile nature of this linker allows for the creation of various PROTACs with diverse target protein specificities, enhancing the potential for therapeutic applications.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.