Biotin-PEG1-NH2

• CAT Number: I044714
• CAS Number: 811442-85-0
• Molecular Formula: C14H26N4O3S
• Molecular Weight: 330.45
• Purity: ≥95%
• Synonyms: N-[2-(2-aminoethoxy)ethyl]-5-[(3aS,4S)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanamide
• InChI: InChI=1S/C14H26N4O3S/c15-5-7-21-8-6-16-12(19)4-2-1-3-11-13-10(9-22-11)17-14(20)18-13/h10-11,13H,1-9,15H2,(H,16,19)(H2,17,18,20)/t10?,11-,13-/m0/s1
• InChIKey: MJCKXPHJERSYIX-KUNJKIHDSA-N
• SMILES: C1C2C(C(S1)CCCCC(=O)NCCOCCN)NC(=O)N2

Biotin-PEG1-NH2 is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

Reference

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
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