Biotin-PEG2-NH-Boc

For research use only. Not for therapeutic Use.

  • CAT Number: I014192
  • CAS Number: 175885-18-4
  • Molecular Formula: C21H38N4O6S
  • Molecular Weight: 474.62
  • Purity: ≥95%
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Biotin-PEG2-NH-Boc(CAT: I014192) is a biotin PEG linker. This compound consists of a biotin group, a PEG chain, and a Boc-protected amino group. Biotin-PEG2-NH-Boc is commonly used in the field of bioconjugation and drug development, particularly in the creation of antibody-drug conjugates (ADCs). The biotin group allows for specific binding to avidin or streptavidin, enabling targeted delivery of the conjugate to biotin-binding proteins or cells. The PEG chain provides flexibility and solubility, and the Boc protection can be removed to expose the amino group to further chemical reactions.


CAS Number 175885-18-4
Synonyms

Biotin-PEG2-NH-Boc;tert-butyl (2-(2-(2-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethoxy)ethoxy)ethyl)carbamate

Molecular Formula C21H38N4O6S
Purity ≥95%
Target PROTAC Linkers
Solubility Soluble in DMSO
InChI InChI=1S/C21H38N4O6S/c1-21(2,3)31-20(28)23-9-11-30-13-12-29-10-8-22-17(26)7-5-4-6-16-18-15(14-32-16)24-19(27)25-18/h15-16,18H,4-14H2,1-3H3,(H,22,26)(H,23,28)(H2,24,25,27)/t15-,16-,18-/m0/s1
InChIKey GCMGCUOONLVCAK-BQFCYCMXSA-N
SMILES O=C1N[C@@]2([H])CS[C@@H](CCCCC(NCCOCCOCCNC(OC(C)(C)C)=O)=O)[C@@]2([H])N1
Reference

</br>1: Deng CY, Long YY, Liu S, Chen ZB, Li C. [Construction of biotin-modified polymeric micelles for pancreatic cancer targeted photodynamic therapy]. Yao Xue Xue Bao. 2015 Aug;50(8):1038-44. Chinese. PubMed PMID: 26669006.</br>2: Zhu W, Song Z, Wei P, Meng N, Teng F, Yang F, Liu N, Feng R. Y-shaped biotin-conjugated poly (ethylene glycol)-poly (epsilon-caprolactone) copolymer for the targeted delivery of curcumin. J Colloid Interface Sci. 2015 Apr 1;443:1-7. doi: 10.1016/j.jcis.2014.11.073. Epub 2014 Dec 6. PubMed PMID: 25526295.</br>3: Ke S, Wright JC, Kwon GS. Avidin-biotin-PEG-CPA complexes as potential EPR-directed therapeutic protein carriers: preparation and characterization. Bioconjug Chem. 2007 Sep-Oct;18(5):1644-50. Epub 2007 Aug 18. PubMed PMID: 17705554.</br>4: Kaiser K, Marek M, Haselgrübler T, Schindler H, Gruber HJ. Basic studies on heterobifunctional biotin-PEG conjugates with a 3-(4-pyridyldithio)propionyl marker on the second terminus. Bioconjug Chem. 1997 Jul-Aug;8(4):545-51. PubMed PMID: 9258454.</br></br>

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