Biotin-PEG2-NH-Boc

For research use only. Not for therapeutic Use.

  • CAT Number: I014192
  • CAS Number: 175885-18-4
  • Molecular Formula: C21H38N4O6S
  • Molecular Weight: 474.62
  • Purity: ≥95%
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Biotin-PEG2-NH-Boc(CAT: I014192) is a biotin PEG linker. This compound consists of a biotin group, a PEG chain, and a Boc-protected amino group. Biotin-PEG2-NH-Boc is commonly used in the field of bioconjugation and drug development, particularly in the creation of antibody-drug conjugates (ADCs). The biotin group allows for specific binding to avidin or streptavidin, enabling targeted delivery of the conjugate to biotin-binding proteins or cells. The PEG chain provides flexibility and solubility, and the Boc protection can be removed to expose the amino group to further chemical reactions.


Catalog Number I014192
CAS Number 175885-18-4
Synonyms

Biotin-PEG2-NH-Boc;tert-butyl (2-(2-(2-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethoxy)ethoxy)ethyl)carbamate

Molecular Formula C21H38N4O6S
Purity ≥95%
Target PROTAC Linkers
Solubility Soluble in DMSO
InChI InChI=1S/C21H38N4O6S/c1-21(2,3)31-20(28)23-9-11-30-13-12-29-10-8-22-17(26)7-5-4-6-16-18-15(14-32-16)24-19(27)25-18/h15-16,18H,4-14H2,1-3H3,(H,22,26)(H,23,28)(H2,24,25,27)/t15-,16-,18-/m0/s1
InChIKey GCMGCUOONLVCAK-BQFCYCMXSA-N
SMILES O=C1N[C@@]2([H])CS[C@@H](CCCCC(NCCOCCOCCNC(OC(C)(C)C)=O)=O)[C@@]2([H])N1
Reference

</br>1: Deng CY, Long YY, Liu S, Chen ZB, Li C. [Construction of biotin-modified polymeric micelles for pancreatic cancer targeted photodynamic therapy]. Yao Xue Xue Bao. 2015 Aug;50(8):1038-44. Chinese. PubMed PMID: 26669006.</br>2: Zhu W, Song Z, Wei P, Meng N, Teng F, Yang F, Liu N, Feng R. Y-shaped biotin-conjugated poly (ethylene glycol)-poly (epsilon-caprolactone) copolymer for the targeted delivery of curcumin. J Colloid Interface Sci. 2015 Apr 1;443:1-7. doi: 10.1016/j.jcis.2014.11.073. Epub 2014 Dec 6. PubMed PMID: 25526295.</br>3: Ke S, Wright JC, Kwon GS. Avidin-biotin-PEG-CPA complexes as potential EPR-directed therapeutic protein carriers: preparation and characterization. Bioconjug Chem. 2007 Sep-Oct;18(5):1644-50. Epub 2007 Aug 18. PubMed PMID: 17705554.</br>4: Kaiser K, Marek M, Haselgrübler T, Schindler H, Gruber HJ. Basic studies on heterobifunctional biotin-PEG conjugates with a 3-(4-pyridyldithio)propionyl marker on the second terminus. Bioconjug Chem. 1997 Jul-Aug;8(4):545-51. PubMed PMID: 9258454.</br></br>

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