For research use only. Not for therapeutic Use.
Biotin-PEG3-acid(CAT: I014194) is a compound consisting of biotin (a vitamin) linked to a polyethylene glycol (PEG) chain with three ethylene glycol units and a terminal carboxylic acid group. This structure combines the specific binding properties of biotin with the hydrophilic and biocompatible characteristics of PEG. Biotin-PEG3-acid is commonly used as a linker or spacer molecule in various bioconjugation and drug delivery applications. Its carboxylic acid group allows for further modification or conjugation with other molecules through amide bond formation or other chemistries.
| Catalog Number | I014194 |
| CAS Number | 252881-76-8 |
| Synonyms | Biotin-PEG3-acid;14-oxo-18-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10-trioxa-13-azaoctadecanoic acid |
| Molecular Formula | C19H33N3O7S |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| Solubility | Soluble in DMSO |
| InChI | InChI=1S/C19H33N3O7S/c23-16(4-2-1-3-15-18-14(13-30-15)21-19(26)22-18)20-6-8-28-10-12-29-11-9-27-7-5-17(24)25/h14-15,18H,1-13H2,(H,20,23)(H,24,25)(H2,21,22,26)/t14-,15-,18-/m0/s1 |
| InChIKey | HRGPPBXEZFBGDJ-MPGHIAIKSA-N |
| SMILES | O=C1N[C@@]2([H])CS[C@@H](CCCCC(NCCOCCOCCOCCC(O)=O)=O)[C@@]2([H])N1 |
| Reference | </br>1: Kim HJ, Miyata K, Nomoto T, Zheng M, Kim A, Liu X, Cabral H, Christie RJ, Nishiyama N, Kataoka K. siRNA delivery from triblock copolymer micelles with spatially-ordered compartments of PEG shell, siRNA-loaded intermediate layer, and hydrophobic core. Biomaterials. 2014 May;35(15):4548-56. doi: 10.1016/j.biomaterials.2014.02.016. Epub 2014 Mar 6. PubMed PMID: 24613051.</br>2: Acton AL, Fante C, Flatley B, Burattini S, Hamley IW, Wang Z, Greco F, Hayes W. Janus PEG-based dendrimers for use in combination therapy: controlled multi-drug loading and sequential release. Biomacromolecules. 2013 Feb 11;14(2):564-74. doi: 10.1021/bm301881h. Epub 2013 Jan 18. PubMed PMID: 23305104.</br>3: Mueller C, Capelle MA, Seyrek E, Martel S, Carrupt PA, Arvinte T, Borchard G. Noncovalent PEGylation: different effects of dansyl-, L-tryptophan-, phenylbutylamino-, benzyl- and cholesteryl-PEGs on the aggregation of salmon calcitonin and lysozyme. J Pharm Sci. 2012 Jun;101(6):1995-2008. doi: 10.1002/jps.23110. Epub 2012 Mar 23. PubMed PMID: 22447529. </br> </br> |
