For research use only. Not for therapeutic Use.
Biotin-PEG3-(CH2)3-NH2 TFA salt (CAT: I014198) is a PEG derivative containing a biotin group and a terminal primary amine group. The amine group can be coupled to carboxyl groups or 5’phosphate groups to form stable amide bonds. The hydrophilic PEG spacer increases solubility in aqueous media and increases membrane impermeability of the molecules conjugated to the biotin compound. It also helps to minimize steric hindrance involved with the binding to avidin molecules. Therefore, Biotin-PEG-amines may be useful in the development of antibody-drug conjugates.
| Catalog Number | I014198 |
| CAS Number | 1374658-86-2 |
| Synonyms | Biotin-PEG3-(CH2)3-NH2 TFA salt;N-(3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide |
| Molecular Formula | C20H38N4O5S |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| IUPAC Name | 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[3-[2-[2-(3-aminopropoxy)ethoxy]ethoxy]propyl]pentanamide |
| InChI | InChI=1S/C20H38N4O5S/c21-7-3-9-27-11-13-29-14-12-28-10-4-8-22-18(25)6-2-1-5-17-19-16(15-30-17)23-20(26)24-19/h16-17,19H,1-15,21H2,(H,22,25)(H2,23,24,26)/t16-,17-,19-/m0/s1 |
| InChIKey | XNGTVIOREZIKAE-LNLFQRSKSA-N |
| SMILES | O=C1N[C@@]2([H])CS[C@@H](CCCCC(NCCCOCCOCCOCCCN)=O)[C@@]2([H])N1 |
| Reference | <br /> |
